NBR1

Neighbor of BRCA1 gene 1

PDB rendering based on 1wj6.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsNBR1 ; 1A1-3B; IAI3B; M17S2
External IDsOMIM: 166945 MGI: 108498 HomoloGene: 7438 GeneCards: NBR1 Gene
Orthologs
SpeciesHumanMouse
Entrez407717966
EnsemblENSG00000188554ENSMUSG00000017119
UniProtQ14596P97432
RefSeq (mRNA)NM_001291571NM_001252220
RefSeq (protein)NP_001278500NP_001239149
Location (UCSC)Chr 17:
41.32 – 41.36 Mb		Chr 11:
101.55 – 101.58 Mb
PubMed search

Neighbor of BRCA1 gene 1 protein is a protein that in humans is encoded by the NBR1 gene.[1][2]

The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled coil motif, which is present in many genes with transformation potential. This gene is located on a region of chromosome 17q21.1 that is in close proximity to tumor suppressor gene BRCA1. Three alternatively spliced variants encoding the same protein have been identified for this gene.[2] One implied function lies in autophagy, where it acts a cargo receptor in selective autophagy. [3]

Interactions

NBR1 has been shown to interact with FEZ1.[4]

References

  1. ↑ Campbell IG, Nicolai HM, Foulkes WD, Senger G, Stamp GW, Allan G, Boyer C, Jones K, Bast RC Jr, Solomon E (Sep 1994). "A novel gene encoding a B-box protein within the BRCA1 region at 17q21.1". Hum Mol Genet 3 (4): 589–594. doi:10.1093/hmg/3.4.589. PMID 8069304.
  2. ↑ 2.0 2.1 "Entrez Gene: NBR1 neighbor of BRCA1 gene 1".
  3. ↑ Kirkin, Vladimir (2009). "A Role for Ubiquitin in Selective Autophagy". Molecular Cell 34.
  4. ↑ Whitehouse, Caroline; Chambers Julie; Howe Kathy; Cobourne Martyn; Sharpe Paul; Solomon Ellen (Jan 2002). "NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube". Eur. J. Biochem. (Germany) 269 (2): 538–545. doi:10.1046/j.0014-2956.2001.02681.x. ISSN 0014-2956. PMID 11856312.

Further reading

  • Miki Y; Swensen J; Shattuck-Eidens D et al. (1994). "A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1". Science 266 (5182): 66–71. doi:10.1126/science.7545954. PMID 7545954.
  • Harshman K; Bell R; Rosenthal J et al. (1995). "Comparison of the positional cloning methods used to isolate the BRCA1 gene". Hum. Mol. Genet. 4 (8): 1259–1266. doi:10.1093/hmg/4.8.1259. PMID 7581362.
  • Nomura N; Nagase T; Miyajima N et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–229. doi:10.1093/dnares/1.5.223. PMID 7584044.
  • Brown MA; Nicolai H; Xu CF et al. (1995). "Regulation of BRCA1". Nature 372 (6508): 733–733. doi:10.1038/372733a0. PMID 7997258.
  • Brown MA; Xu CF; Nicolai H et al. (1996). "The 5' end of the BRCA1 gene lies within a duplicated region of human chromosome 17q21". Oncogene 12 (12): 2507–13. PMID 8700509.
  • Dimitrov S, Brennerova M, Forejt J (2001). "Expression profiles and intergenic structure of head-to-head oriented Brca1 and Nbr1 genes". Gene 262 (1–2): 89–98. doi:10.1016/S0378-1119(00)00549-7. PMID 11179671.
  • Whitehouse C; Chambers J; Howe K et al. (2002). "NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube". Eur. J. Biochem. 269 (2): 538–545. doi:10.1046/j.0014-2956.2001.02681.x. PMID 11856312.
  • Wistow G; Bernstein SL; Ray S et al. (2002). "Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium". Mol. Vis. 8: 185–95. PMID 12107412.
  • Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Lamark T; Perander M; Outzen H et al. (2003). "Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins". J. Biol. Chem. 278 (36): 34568–34581. doi:10.1074/jbc.M303221200. PMID 12813044.
  • Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS; Wagner L; Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Lange S; Xiang F; Yakovenko A et al. (2005). "The kinase domain of titin controls muscle gene expression and protein turnover". Science 308 (5728): 1599–1603. doi:10.1126/science.1110463. PMID 15802564.
  • Rual JF; Venkatesan K; Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514.