NADH dehydrogenase (quinone)
NADH dehydrogenase (quinone) | |||||||||
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Identifiers | |||||||||
EC number | 1.6.99.5 | ||||||||
CAS number | 37256-36-3 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / EGO | ||||||||
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In enzymology, a NADH dehydrogenase (quinone) (EC 1.6.99.5) is an enzyme that catalyzes the chemical reaction
- NADH + H+ + acceptor NAD+ + reduced acceptor
The 3 substrates of this enzyme are NADH, H+, and acceptor, whereas its two products are NAD+ and reduced acceptor.
This enzyme belongs to the family of oxidoreductases, specifically those acting on NADH or NADPH with other acceptors. The systematic name of this enzyme class is NADH:(quinone-acceptor) oxidoreductase. Other names in common use include reduced nicotinamide adenine dinucleotide (quinone) dehydrogenase, NADH-quinone oxidoreductase, NADH ubiquinone oxidoreductase, DPNH-menadione reductase, D-diaphorase, and NADH2 dehydrogenase (quinone), and mitochondrial (mt) complex I. This enzyme participates in oxidative phosphorylation. Several compounds are known to inhibit this enzyme, including AMP, and 2,4-Dinitrophenol.
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2FUG.
References
- Koli AK, Yearby C, Scott W, Donaldson KO (1969). "Purification and properties of three separate menadione reductases from hog liver". J. Biol. Chem. 244 (4): 621–9. PMID 4388793.