N,N-Diisopropylcarbodiimide

N,N'-Diisopropylcarbodiimide

Identifiers
Abbreviations	DIPC
CAS Registry Number	693-13-0
ChemSpider	12211
InChI InChI=1S/C7H14N2/c1-6(2)8-5-9-7(3)4/h6-7H,1-4H3 Key: BDNKZNFMNDZQMI-UHFFFAOYSA-N InChI=1/C7H14N2/c1-6(2)8-5-9-7(3)4/h6-7H,1-4H3 Key: BDNKZNFMNDZQMI-UHFFFAOYAW
Jmol-3D images	Image
PubChem	12734
SMILES CC(C)N=C=NC(C)C
Properties
Molecular formula	C7H14N2
Molar mass	126.20 g·mol−1
Appearance	Liquid
Density	0.806 g/mL
Boiling point	145 to 148 °C (293 to 298 °F; 418 to 421 K)
Hazards
MSDS	External MSDS
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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Infobox references

N,N′-Diisopropylcarbodiimide is a carbodiimide used in peptide synthesis. As a liquid, it is easier to handle than the commonly used N,N′-dicyclohexylcarbodiimide, especially since its urea is soluble in most organic solvents, facilitating work-up. Users should be careful during handling since it is toxic and harmful to eyes.

Further reading

• Angell, Y (1994). "Comparative studies of the coupling of N-methylated, sterically hindered amino acids during solid-phase peptide synthesis". Tetrahedron Lett. 35 (33): 5981. doi:10.1016/0040-4039(94)88054-9. 
• Izdebski, JAN; Orlowska, Alicja; Anulewicz, Romana; Witkowska, EWA; Fiertek, Dariusz (1994). "Reinvestigation of the reactions of carbodiimides with alkoxycarbonylamino acid symmetrical anhydrides : Isolation of two N-acylureas". Int. J. Pept. Protein Res. 43 (2): 184. doi:10.1111/j.1399-3011.1994.tb00521.x.