Muzolimine
Muzolimine
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Systematic (IUPAC) name |
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5-amino-2-[1-(3,4-dichlorophenyl)ethyl]-4H-pyrazol-3-one |
Clinical data |
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Identifiers |
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C03CD01 |
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PubChem |
CID 41386 |
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ChemSpider |
37766 |
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UNII |
07Z36289ZX Y |
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KEGG |
D05093 Y |
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Chemical data |
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Formula |
C11H11Cl2N3O |
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272.13 g/mol |
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SMILES
- CC(C1=CC(=C(C=C1)Cl)Cl)N2C(=O)CC(=N2)N
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InChI=1S/C11H11Cl2N3O/c1-6(16-11(17)5-10(14)15-16)7-2-3-8(12)9(13)4-7/h2-4,6H,5H2,1H3,(H2,14,15)
Key:RLWRMIYXDPXIEX-UHFFFAOYSA-N
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Y (what is this?) (verify) |
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Muzolimine is a loop diuretic.[1] It is a pyrazole diuretic which was used for treatment of hypertension but was withdrawn worldwide because of severe neurological side effects.[2]
References
- ↑ Wangemann, P.; Braitsch, R.; Greger, R. (1987). "The diuretic effect of muzolimine". Pflugers Archiv : European journal of physiology 410 (6): 674–676. PMID 3449804.
- ↑ Reyes, A. J.; Leary, W. P. (1993). "Clinicopharmacological reappraisal of the potency of diuretics". Cardiovascular Drugs and Therapy 7: 23–28. doi:10.1007/BF00877955. PMID 8435374.
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| Sulfonamides (and etacrynic acid) | |
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| Potassium-sparing (at CD) | |
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| Osmotic diuretics (PT, DL) | |
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| Vasopressin receptor antagonists (DCT and CD) | |
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| Other | |
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| Description |
- Anatomy
- Arteries
- head and neck
- arms
- chest
- abdomen
- legs
- Veins
- head and neck
- arms
- chest
- abdomen and pelvis
- legs
- Development
- Cells
- Physiology
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| Disease |
- Congenital
- Neoplasms and cancer
- Lymphatic vessels
- Injury
- Vasculitis
- Other
- Symptoms and signs
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| Treatment |
- Procedures
- Drugs
- beta blockers
- channel blockers
- diuretics
- nonsympatholytic vasodilatory antihypertensives
- peripheral vasodilators
- renin–angiotensin system
- sympatholytic antihypertensives
- vasoprotectives
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