Murid herpesvirus 4
| Murid herpesvirus 4 | |
|---|---|
| Virus classification | |
| Group: | Group I (dsDNA) |
| Family: | Herpesviridae |
| Subfamily: | Gammaherpesvirinae |
| Genus: | Rhadinovirus |
| Species: | Murid herpesvirus 4 (MuHV 4) |
Murid herpesvirus 4 (MuHV 4) is a virus in the genus Rhadinovirus. It is a member of the subfamily Gammaherpesvirinae in the family Herpesviridae. MuHV 4 infects mice via the nasal passages and causes an acute infectious mononucleosis-like syndrome with elevated levels of leukocytes, and shifts in the relative proportion of lymphocytes along with the appearance of atypical mononuclear cells.[1] Murid herpesvirus 4 currently serves as a model for study of human gamma-herpesvirus pathogenesis.[2]
Seven strains of MuHV 4 have been isolated, including the following six:
- MHV-Šum
- MHV-60
- MHV-68
- MHV-72
- MHV-76
- MHV-4556
References
- ↑ Jela Mistríková, and Július Rajčáni. "Comparison of pathogenic properties of the murid gammaherpesvirus (MuHV 4) strains: a role for immunomodulatory proteins encoded by the left (5'-)end of the genome". Central European Journal of Biology 3 (1 / March, 2008).
- ↑ Valovicová M, Rezuchorá I, Macáková K, Petrová P, Matis J, Kúdelová M (2006). "Murine gammaherpesvirus (MHV) MK3 gene sequence diversity among 72, 4556, and 68 strains". Virus Genes. 2006 Aug;33(1):51-8 (1): 51–8. doi:10.1007/s11262-005-0038-4. PMID 16791419.