Missouri Route 53
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| Route information | ||||
| Maintained by MoDOT | ||||
| Length: | 33 mi (53 km) | |||
| Existed: | 1922 – present | |||
| Major junctions | ||||
| South end: |
 Route 25 in Holcomb | |||
| North end: |
    US 160 / US 67 Bus. in Poplar Bluff | |||
| Highway system | ||||
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Missouri Highways
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Route 53 is a highway in southeastern Missouri. Its northern terminus is at Business U.S. Route 67/U.S. Route 160 in Poplar Bluff. Its southern terminus is at Route 25 in Holcomb.
Route 53 is one of the original state highways and has remained essentially unchanged since 1922.