mir-BART2 microRNA precursor family

mir-BART2 microRNA precursor family
Predicted secondary structure and sequence conservation of mir-BART2
Identifiers
Symbol mir-BART2
Rfam RF00364
miRBase MI0001068
Other data
RNA type Gene; miRNA
Domain(s) Viruses
GO 0035195 0035068
SO 0001244

The mir-BART2 microRNA precursor found in Human herpesvirus 4 (Epstein-Barr virus) and Cercopithicine herpesvirus 15. mir-BART2 is expressed in all stages of infection but expression is significantly elevated in the lytic stage. In Epstein-Barr virus, mir-BART2 is found in the intronic regions of the BART (Bam HI-A region rightward transcript) gene whose function is unknown. mir-BART2 is thought to target the virally encoded DNA polymerase BALF5 for degradation. The mature sequence is excised from the 5' arm of the hairpin.[1]

References

  1. ↑ Pfeffer, S; Zavolan M, Grasser FA, Chien M, Russo JJ, Ju J, John B, Enright AJ, Marks D, Sander C, Tuschl T (2004). "Identification of Virus-Encoded MicroRNAs". Science 304 (5671): 734–736. doi:10.1126/science.1096781. PMID 15118162.

External links