Mir-5 microRNA precursor family
| mir-5 | ||
|---|---|---|
| Identifiers | ||
| Symbol | mir-5 | |
| Rfam | RF00854 | |
| miRBase family | 2 | |
| Other data | ||
| RNA type | microRNA | |
| Domain(s) | Eukaryota; | |
In molecular biology mir-5 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. mir-5 has been implicated in regulation of VEGF in an experiment where a plasmid containing a cluster of mir-5, mir-10 and mir-7 was shown to down-regulate VEGF by 75%.[1] mir-5 in chicken has been implicated in targeting genes involved in metabolism.[2]
See also
External references
- ↑ Pihlmann, M; Askou, AL; Aagaard, L; Bruun, GH; Svalgaard, JD; Holm-Nielsen, MH; Dagnaes-Hansen, F; Bek, T; Mikkelsen, JG; Jensen, TG; Corydon, TJ (May 2012). "Adeno-associated virus-delivered polycistronic microRNA-clusters for knockdown of vascular endothelial growth factor in vivo". Journal of Gene Medicine 14 (5): 328–338. doi:10.1002/jgm.2623. PMID 22438271.
- ↑ Hicks, JA; Trakooljul, N; Liu, HC (April 2010). "Discovery of chicken microRNAs associated with lipogenesis and cell proliferation". Physiological Genomics 41 (2): 185–193. doi:10.1152/physiolgenomics.00156.2009. PMID 20103699.