Miglitol
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Systematic (IUPAC) name | |
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(2R,3R,4R,5S)-1-(2-hydroxyethyl)-2-(hydroxymethyl) piperidine-3,4,5-triol | |
Clinical data | |
Trade names | Glyset |
AHFS/Drugs.com | monograph |
MedlinePlus | a601079 |
Licence data | US FDA:link |
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Oral | |
Pharmacokinetic data | |
Bioavailability | Dose-dependent |
Protein binding | Negligible (<4.0%) |
Metabolism | Nil |
Half-life | 2 hours |
Excretion | Renal (95%) |
Identifiers | |
72432-03-2 ![]() | |
A10BF02 | |
PubChem | CID 441314 |
DrugBank |
DB00491 ![]() |
ChemSpider |
390074 ![]() |
UNII |
0V5436JAQW ![]() |
KEGG |
D00625 ![]() |
ChEMBL |
CHEMBL1561 ![]() |
Chemical data | |
Formula | C8H17NO5 |
207.224 g/mol | |
SMILES
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Physical data | |
Density | 1.458 g/cm3 |
Melting point | 114 °C (237 °F) |
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Miglitol is an oral anti-diabetic drug that acts by inhibiting the ability of the patient to break down complex carbohydrates into glucose. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into monosaccharides which can be absorbed by the body.[1]
Miglitol, and other structurally-related iminosugars, inhibit glycoside hydrolase enzymes called alpha-glucosidases. Since miglitol works by preventing digestion of carbohydrates, it lowers the degree of postprandial hyperglycemia. It must be taken at the start of main meals to have maximal effect.[2] Its effect will depend on the amount of non-monosaccharide carbohydrates in a person's diet.
In contrast to acarbose (another alpha-glucosidase inhibitor), miglitol is systemically absorbed; however, it is not metabolized and is excreted by the kidneys.
See also
References
- ↑ "Migliotl: MedlinePlus Drug Information". MedlinePlus. National Institudes of Health. 1 September 2010. Retrieved 13 April 2013.
- ↑ "Glyset (miglitol) tablets label - Accessdata FDA". Drugs@FDA. U.S. Food and Drug Administration. August 2012. Retrieved 13 April 2013.
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