Microtransplantation
""Microtransplantation"" is the application of stem cell to treat hematogolocial disease. It is developed by Huisheng Ai and his medical team, including Guo Mei from Newcell Biotech. Microtransplantation uses allogeneic peripheral blood stem cell transplantation in treating hematological cancer. The term ""microtransplantation""comes from its mechanism of reaching microchimerism in order to result graft-versus-leukemia effect. The research of microtransplantation has further demonstrated the effect microchimerism in medical practice. Unlike conventional stem cell transplantation in hematological cancer practice, microtransplantation uses human leukocyte antigen (HLA) mismatch stem cell in transplantation, thus presenting a new medical exploration field.
Medical Uses
Microtransplantation is applied after chemotherapy to treat cancer patients with acute myeloid leukemia. [1]During chemotherapy, most growing cells are killed by the cytotoxic agents. However, the proportion of agents applied as less than conventional amount, leaving the immune to recover at faster pace. A short moment after chemotherapy, granulocyte colony-stimulating factor (G-CSF or GCSF) mobilized mismatched HLA stem cell will be infused into the receiver to reintroduces functional immune system. [2]The transplanted cells will generate an immune response that helps to kill off the cancer cell; conventional allogeneic stem cell transplant might over-perform, causing graft vs host disease (GVHD), which could be fatal, while the practices of microtransplantation has shown none GVHD till present.