MicC RNA
| MicC RNA | |
|---|---|
 | |
| Predicted secondary structure and sequence conservation of MicC | |
| Identifiers | |
| Symbol | MicC |
| Alt. Symbols | IS063 |
| Rfam | RF00121 |
| Other data | |
| RNA type | Gene; sRNA |
| Domain(s) | Bacteria |
| SO | 0000655 |
The MicC non-coding RNA (previously known as IS063 [1]) is located between the ompN and ydbK genes in E. coli. This RNA is thought to be a regulator of the expression level of the OmpC porin protein, with a 5' region of 22 nucleotides potentially forming an antisense interaction with the ompC mRNA. Along with MicF RNA this family may act in conjunction with EnvZ-OmpR two-component system to control the OmpF/OmpC protein ratio in response to a variety of environmental stimuli.[2]
See also
References
- ↑ Chen, S; Lesnik EA; Hall TA; Sampath R; Griffey RH; Ecker DJ; Blyn LB (2002). "A bioinformatics based approach to discover small RNA genes in the Escherichia coli genome". Biosystems 65 (2–3): 157–177. doi:10.1016/S0303-2647(02)00013-8. PMID 12069726.
- ↑ Chen, S; Zhang A; Blyn LB; Storz G (2004). "MicC, a Second Small-RNA Regulator of Omp Protein Expression in Escherichia coli". J Bacteriol 186 (20): 6689–6697. doi:10.1128/JB.186.20.6689-6697.2004. PMC 522180. PMID 15466019.
Further reading
- Pfeiffer, V.; Papenfort, K.; Lucchini, S.; Hinton, J. C. D.; Vogel, J. �R. (2009). "Coding sequence targeting by MicC RNA reveals bacterial mRNA silencing downstream of translational initiation". Nature Structural & Molecular Biology 16 (8): 840. doi:10.1038/nsmb.1631.