miR-191

miR-191
Conserved secondary structure of miR-191 microRNA precursor
Identifiers
Symbol miR-191
Alt. Symbols MIR191
Rfam RF00764
miRBase MI0000465
miRBase family MIPF0000194
Entrez 406966
HUGO 31561
RefSeq NR_029690
Other data
RNA type miRNA
Domain(s) Mammalia
GO 0035195
SO 0001244
Locus Chr. 3 p21.31

miR-191 is a family of microRNA precursors found in mammals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer.[1] This sequence then associates with RISC which effects RNA interference.[2]

miR-191 has been found to be dysregulated in a large number of different types of human tumour, including those of colorectal,[3] breast and prostate cancers.[4] Despite these cancer links, target genes of the mature miRNA have not been characterised, and it is not known which factors lead to its dysregulation in certain tumour cells.[5]

The expression profile of miR-191 could be implemented in prognosis of acute myeloid leukaemia, with higher than average levels of miR-191 suggesting a lower survival probability.[6]

References

  1. ↑ Ambros, V (2001-12-28). "microRNAs: tiny regulators with great potential.". Cell 107 (7): 823–6. doi:10.1016/S0092-8674(01)00616-X. PMID 11779458.
  2. ↑ Gregory, RI; Chendrimada, TP, Cooch, N, Shiekhattar, R (2005-11-18). "Human RISC couples microRNA biogenesis and posttranscriptional gene silencing.". Cell 123 (4): 631–40. doi:10.1016/j.cell.2005.10.022. PMID 16271387.
  3. ↑ Xi, Y; Formentini, A; Chien, M; Weir, DB; Russo, JJ; Ju, J; Kornmann, M; Ju, J (2006). "Prognostic Values of microRNAs in Colorectal Cancer.". Biomarker insights 2: 113–121. PMC 2134920. PMID 18079988.
  4. ↑ Volinia, S; Calin, GA, Liu, CG, Ambs, S, Cimmino, A, Petrocca, F, Visone, R, Iorio, M, Roldo, C, Ferracin, M, Prueitt, RL, Yanaihara, N, Lanza, G, Scarpa, A, Vecchione, A, Negrini, M, Harris, CC, Croce, CM (2006-02-14). "A microRNA expression signature of human solid tumors defines cancer gene targets.". Proceedings of the National Academy of Sciences of the United States of America 103 (7): 2257–61. doi:10.1073/pnas.0510565103. PMC 1413718. PMID 16461460.
  5. ↑ Shen, J; DiCioccio, R; Odunsi, K; Lele, SB; Zhao, H (2010-02-18). "Novel genetic variants in miR-191 gene and familial ovarian cancer.". BMC cancer 10: 47. doi:10.1186/1471-2407-10-47. PMC 2831822. PMID 20167074.
  6. ↑ Garzon, R; Volinia, S, Liu, CG, Fernandez-Cymering, C, Palumbo, T, Pichiorri, F, Fabbri, M, Coombes, K, Alder, H, Nakamura, T, Flomenberg, N, Marcucci, G, Calin, GA, Kornblau, SM, Kantarjian, H, Bloomfield, CD, Andreeff, M, Croce, CM (2008-03-15). "MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia.". Blood 111 (6): 3183–9. doi:10.1182/blood-2007-07-098749. PMC 2265455. PMID 18187662.

External links