Methylhomatropine

Homatropine methyl bromide
Systematic (IUPAC) name
(N,N-dimethyl-8-azoniabicyclo[3.2.1]oct-3-yl) 2-hydroxy-2-phenylacetate bromide
Clinical data
Identifiers
80-49-9
A02BX03
PubChem CID 6646
DrugBank DB00725
ChemSpider 6394 Yes
UNII 68JRS2HC1C Yes
ChEMBL CHEMBL1200851
Chemical data
Formula C17H24BrNO3
370.26 g/mol
 Yes (what is this?)  (verify)

Homatropine methylbromide or Methylhomatropine bromide is a quaternary ammonium salt of methylhomatropine. It is a peripherally acting anticholinergic medication that inhibits muscarinic acetylcholine receptors and thus the parasympathetic nervous system. It does not cross the blood–brain barrier. It is used, in addition to papaverine, as component of mild drugs that help "flush" the bile.

Certain preparations of drugs such as hydrocodone are mixed with a small, sub-therapeutic amount homatropine methylbromide to discourage intentional overdose.[1]

Contraindications

References

  1. ↑ "Hydromet (Hydrocodone Bitartrate and Homatropine Methylbromide)". DailyMed. NIH.