Methyldesorphine
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| Systematic (IUPAC) name | |
|---|---|
| (5α)-6,17-Dimethyl-6,7-didehydro-4,5-epoxymorphinan-3-ol | |
| Clinical data | |
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| Identifiers | |
16008-36-9  | |
| None | |
| PubChem | CID 5362518 |
| ChemSpider |
4515065  |
| UNII |
Y460N7W76B |
| Synonyms | 3-Hydroxy-6,N-dimethyl- 4,5-epoxymorphin-6-en |
| Chemical data | |
| Formula | C18H21NO2 |
| 283.36 g/mol | |
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SMILES
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Methyldesorphine is an opioid analgesic. First synthesized in Germany in 1940 and patented in the USA in 1952,[1] it has a high potential for abuse as with any potent opioid agonist, and is sometimes found along with desomorphine as a component of the home-made opioid mixture known as "Krokodil" used in Russia and the neighboring former Soviet republics.[2] It is approximately 15 times more potent than morphine as an analgesic[3][4] but if the 6-7 bond is saturated, the β isomer is some 50 times more potent than morphine.
Methyldesorphine is listed as a Schedule I Narcotic controlled substance under the Controlled Substances Act 1970 in the United States with a DEA ACSCN of 9302 and zero annual aggregate manufacturing quota. The free base conversion ratio of the hydrochloride is 0.89.[5]
See also
References
- ↑ US patent 2694068, Payne, G. B. et al., "Δ6-DESOXYMORPHINE COMPOUNDS AND PROCESS OF PRODUCING THE SAME", published 1952-08-05, issued 1954-09-11
- ↑ Savchuk, S. A.; Barsegyan, S. S.; Barsegyan, I. B.; Kolesov, G. M. (2008). "Chromatographic Study of Expert and Biological Samples Containing Desomorphine". Journal of Analytical Chemistry 63 (4): 361–370. doi:10.1007/s10809-008-4009-5.
- ↑ Casy, A. F.; Parfitt, R. Y. (1986). Opioid Analgesics, Chemistry and Receptors. New York: Plenum Press. pp. 37–38. ISBN 0-306-42130-5.
- ↑ Lenz, G. R.; Evans, S. M.; Walters, D. E.; Hopfinger, A. J. (1986). Opiates. Academic Press. p. 63. ISBN 978-0-12-443830-9.
- ↑ http://www.deadiversion.usdoj.gov/quotas/conv_factor/index.html