Methyl hydroxychalcone

Methyl hydroxychalcone

Names
IUPAC name (E)-3-(3-hydroxyphenyl)-1-(3-methylphenyl)prop-2-en-1-one
Other names MCHP 3'-Methyl-3-hydroxychalcone
Identifiers
CAS Registry Number	153976-41-1 Y
ChemSpider	4944650
InChI InChI=1S/C16H14O2/c1-12-4-2-6-14(10-12)16(18)9-8-13-5-3-7-15(17)11-13/h2-11,17H,1H3/b9-8+ Key: GPJXEEMHEDUKIP-CMDGGOBGSA-N InChI=1/C16H14O2/c1-12-4-2-6-14(10-12)16(18)9-8-13-5-3-7-15(17)11-13/h2-11,17H,1H3/b9-8+ Key: GPJXEEMHEDUKIP-CMDGGOBGBY
Jmol-3D images	Image
PubChem	6440383
SMILES CC1=CC=CC(=C1)C(=O)C=CC2=CC(=CC=C2)O
Properties
Chemical formula	C16H14O2
Molar mass	238.28 g/mol
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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Infobox references

Methyl hydroxychalcone is a chalconoid found in cinnamon. It was thought to be an insulin mimetic, improving insulin response of diabetics.^[1] It has since been determined that a flavonoid (cinnamtannin B1) is responsible for the insulin-like biological activity.^[2]

See also

• Anti-diabetic medication

References

1. ↑ Karalee J. Jarvill-Taylor, PhD; Richard A. Anderson, PhD; Donald J. Graves, PhD (August 1, 2001). "A hydroxychalcone derived from cinnamon functions as a mimetic for insulin in 3T3-L1 adipocytes". J Am Coll Nutr. 20 (4): 327–36. PMID 11506060. Archived from the original on 2004-08-11. Retrieved 2014-02-27. 
2. ↑ Anderson; Broadhurst, CL; Polansky, MM; Schmidt, WF; Khan, A; Flanagan, VP; Schoene, NW; Graves, DJ (January 2004). "Isolation and characterization of polyphenol type-A polymers from cinnamon with insulin-like biological activity". J Agric Food Chem. 52 (1): 65–70. doi:10.1021/jf034916b. PMID 14709014.