Mesulergine

Mesulergine
Systematic (IUPAC) name
N'-[(8α)-1,6-dimethylergolin-8-yl)-N,N-dimethylsulfamide
Clinical data
Identifiers
64795-35-3 
PubChem CID 68848
IUPHAR ligand 206
ChemSpider 62081 Yes
UNII SML95FK06I Yes
ChEBI CHEBI:73378 
ChEMBL CHEMBL462903 
Chemical data
Formula C18H26N4O2S
362.49 g/mol
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Mesulergine is a psychoactive drug of the ergoline chemical class that acts on serotonin and dopamine receptors.[1][2]

The compound had entered clinical trials for the treatment of Parkinson's disease, however further development was halted due to adverse histological abnormalities in rats.[3]

See also

References

  1. ↑ Closse A (May 1983). "[3H]-Mesulergine, a selective ligand for serotonin-2 receptors". Life Sci. 32 (21): 2485–95. doi:10.1016/0024-3205(83)90375-2. PMID 6855451.
  2. ↑ Markstein R (November 1983). "Mesulergine and its 1,20-N,N-bidemethylated metabolite interact directly with D1- and D2-receptors". Eur. J. Pharmacol. 95 (1-2): 101–7. doi:10.1016/0014-2999(83)90272-8. PMID 6230246.
  3. ↑ Dupont E, Mikkelsen B, Jakobsen J (April 1986). "Mesulergine in early Parkinson's disease: a double blind controlled trial". J. Neurol. Neurosurg. Psychiatr. 49 (4): 390–5. doi:10.1136/jnnp.49.4.390. PMC 1028763. PMID 3517235.