Mertansine
Names | |
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Other names
Maytansinoid DM1 N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine | |
Identifiers | |
ChEBI | CHEBI:82755 |
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Jmol-3D images | Image |
PubChem | 11343137 |
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Properties | |
Molecular formula |
C35H48ClN3O10S |
Molar mass | 738.29 g·mol−1 |
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa) | |
verify (what is: / ?) | |
Infobox references | |
Mertansine refers to the thiol-containing maytansinoid, DM1 (N2’-deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) attached to a monoclonal antibody through reaction of the thiol group with the SPP (N-succinimidyl 4-(2-pyridyldithio)) linker to create an antibody-drug conjugate or ADC. Experimental ADCs with the SPP-DM1 design include lorvotuzumab mertansine.
DM1 can also be linked to an antibody using the SMCC (4-(3-mercapto-2,5-dioxo-1-pyrrolidinylmethyl)-cylohexanecarboxylic acid) linker, in which case the International Nonproprietary Name of the conjugate is formed contains the word emtansine. DM1 and its attachment via these linkers result from ImmunoGen Inc research.
- Trastuzumab emtansine (T-DM1), an anti-HER2/neu antibody-drug conjugate[1][2]