Mequinol
 | |
| Systematic (IUPAC) name | |
|---|---|
| 4-Methoxyphenol | |
| Clinical data | |
| AHFS/Drugs.com | International Drug Names |
| MedlinePlus | a682437 |
| |
| Topical | |
| Identifiers | |
150-76-5  | |
| D11AX06 | |
| PubChem | CID 9015 |
| ChemSpider |
8665 |
| UNII |
6HT8U7K3AM |
| KEGG |
D04926 |
| ChEMBL |
CHEMBL544 |
| Synonyms | 4-Hydroxyanisole; para-Guaiacol |
| Chemical data | |
| Formula | C7H8O2 |
| 124.13722 g/mol | |
| |
| Physical data | |
| Density | 1.55 g/cm3 |
| Melting point | 52.5 °C (126.5 °F) |
| Boiling point | 243 °C (469 °F) |
| (what is this?) (verify) | |
Mequinol, or 4-Methoxyphenol, is a phenol used in dermatology[1] and organic chemistry.[2]
Uses
Dermatology
Mequinol is a common active ingredient in topical drugs used for skin depigmentation. As a topical drug Mequinol is often mixed with tretinoin, a topical retinoid. A common formulation for this drug is an ethanolic solution of 2% Mequinol and 0.01% tretinoin by mass.[1] Dermatologists commonly prescribe the drug to treat solar lentigines, liver spots, or age spots.
Lower dosages of mequinol have been used in conjunction with a Q-switched laser to depigment skin in patients with disseminated idiopathic vitiligo.[3]
Organic chemistry
In organic chemistry 4-Methoxyphenol is used to inhibit the radical polymerization of monomers (e.g. acrylates or styrene monomers).[2]
Preparation
4-Methoxyphenol is produced from p-benzoquinone and methanol via a free radical reaction.[4][5]
See also
- Monobenzone (benzyloxyphenol)
- Hydroquinone
- Guaiacol
- 2-Hydroxy-5-methoxybenzaldehyde
References
- ↑ 1.0 1.1 Stiefel Laboratories, Inc. "Full Prescribing Information". US Food and Drug Admistration. Retrieved 2 January 2015.
- ↑ 2.0 2.1 Hudnall, Phillip M. (2000). "Hydroquinone". Ullmann's Encyclopedia of Industrial Chemistry. doi:10.1002/14356007.a13_499.
- ↑ Komen, L.; Zwertbroek, L.; Burger, S.J.; van der Veen, J.P.W.; de Rie, M.A.; Wolkerstorfer, A. (2013). "Q-switched laser depigmentation in vitiligo, most effective in active disease". British Journal of Dermatology 169 (6): 1246–1251. doi:10.1111/bjd.12571.
- ↑ Cristian, Gambarotti; Lucio, Melone; Carlo, Punta; Suresh Udhavrao, Shisodia (2013). "Selective Monoetherification of 1,4-Hydroquinone Promoted by NaNO2". Current Organic Chemistry 17 (10): 1108–1113.
- ↑ Correale, Mariano; Panseri, Pietro; Romano, Ugo; Minisci, Francesco. "Process for the preparation of mono-ethers of hydroquinones US4933504A". Google Patents. Enichem Synthesis S.P.A. Retrieved 2 January 2015.
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