Membrane-bound transcription factor peptidase, site 2
| membrane-bound transcription factor peptidase, site 2 | |
|---|---|
| Identifiers | |
| Symbol | MBTPS2 |
| Alt. symbols | S2P |
| Entrez | 51360 |
| HUGO | 15455 |
| OMIM | 300294 |
| RefSeq | NM_015884 |
| UniProt | O43462 |
| Other data | |
| EC number | 3.4.24.85 |
| Locus | Chr. X p22.1-p22.2 |
Membrane-bound transcription factor peptidase, site 2 also known as Site-2 Protease (S2P) is an enzyme (EC 3.4.24.85) encoded by the MBTPS2 gene which liberates the N-terminal fragment of sterol regulatory element binding protein (SREBP) transcription factors from membranes.[1][2] S2P cleaves the transmembrane domain of SREPB, making it a member of the class of intramembrane proteases.
See also
References
- ↑ Brown MS, Goldstein JL (1999). "A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11041–8. doi:10.1073/pnas.96.20.11041. PMC 34238. PMID 10500120.
- ↑ Rawson RB, Zelenski NG, Nijhawan D, Ye J, Sakai J, Hasan MT, Chang TY, Brown MS, Goldstein JL (1997). "Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs". Mol. Cell 1 (1): 47–57. doi:10.1016/S1097-2765(00)80006-4. PMID 9659902.
External links
- SREBP site 2 protease at the US National Library of Medicine Medical Subject Headings (MeSH)