Membrane-bound transcription factor peptidase, site 1
membrane-bound transcription factor peptidase, site 1 | |
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Identifiers | |
Symbol | MBTPS1 |
Alt. symbols | S1P SKI-1 |
Entrez | 8720 |
HUGO | 15456 |
OMIM | 603355 |
RefSeq | NM_003791 |
UniProt | Q14703 |
Other data | |
EC number | 3.4.21.112 |
Locus | Chr. 16 q24 |
Membrane-bound transcription factor peptidase, site 1 also known as Site-1 Protease (S1P) or Subtilisin kexin isozyme-1 (SKI-1) is an enzyme (EC 3.4.21.112) encoded by the MBTPS1 gene which cleaves the endoplasmic reticulum loop of sterol regulatory element binding protein (SREBP) transcription factors.[1][2]
See also
References
- ↑ Brown MS, Goldstein JL (1999). "A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11041–8. doi:10.1073/pnas.96.20.11041. PMC 34238. PMID 10500120.
- ↑ Nakajima T, Iwaki K, Kodama T, Inazawa J, Emi M (2000). "Genomic structure and chromosomal mapping of the human site-1 protease (S1P) gene". J. Hum. Genet. 45 (4): 212–7. doi:10.1007/s100380070029. PMID 10944850.
External links
- site-1 protease at the US National Library of Medicine Medical Subject Headings (MeSH)
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