Medicarpin

Medicarpin
Chemical structure of medicarpin
Names
IUPAC name
9-Methoxy-6a,11a-dihydro-6H-[1]benzofuro[3,2c]chromen-3-ol
Other names
3-Hydroxy-9-methoxypterocarpan
Identifiers
32383-76-9 Yes
ChEBI CHEBI:100 
ChEMBL ChEMBL238823 
ChemSpider 298082 
Jmol-3D images Image
KEGG C10503 
PubChem 623060
Properties
C16H14O4
Molar mass 270.27 g/mol
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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Infobox references

Medicarpin is a pterocarpan, a derivative of isoflavonoids.

Natural occurrences

Medicarpin is found in Medicago truncatula and Swartzia madagascariensis. It can also be found in Maackia amurensis cell cultures.[1]

The root nodule formation by Sinorhizobium meliloti[2] is apparently dependent on the flavonoids pathway.[3]

Metabolism

Pterocarpin synthase has 3 substrates : medicarpin, NADP+ and H2O, and 3 products : vestitone, NADPH and H+.[4]

References

  1. Isoflavonoid production by callus cultures of Maackia amurensis. S.A Fedoreyev, T.V Pokushalov, M.V Veselova, L.I Glebko, N.I Kulesh, T.I Muzarok, L.D Seletskaya, V.P Bulgakov and Yu.N Zhuravlev, Fitoterapia, 1 August 2000, Volume 71, Issue 4, Pages 365–372, doi:10.1016/S0367-326X(00)00129-5
  2. Dakora, F. D., Joseph, C. M., & D. A. Phillips (1993). "Alfalfa (Medicago sativa L.) Root Exudates Contain Isoflavonoids in the Presence of Rhizobium meliloti.". Plant Physiol. 101 (3): 819–824. PMC 158695. PMID 12231731.
  3. Wasson, A. P. (2006). "Silencing the Flavonoid Pathway in Medicago truncatula Inhibits Root Nodule Formation and Prevents Auxin Transport Regulation by Rhizobia". The Plant Cell Online 18: 1617. doi:10.1105/tpc.105.038232.
  4. Lining Guo, Richard A. Dixon and Nancy L. Paival (1994). "Conversion of Vestitone to Medicarpin in Alfalfa (Medicago sativa L.) Is Catalyzed by Two Independent Enzymes. Identification, Purification, and Characterization of Vestitone Reductase and 7,2’-Dihydroxy-4’-MethoxyIsoflavanol Dehydratase" (PDF). Journal of Biological Chemistry 269 (35): 22372–22378. PMID 8071365.