Maitansine

Maitansine

Names
Other names Maytansin
Identifiers
CAS Registry Number	35846-53-8 Y
ChEBI	CHEBI:6701 N
ChEMBL	ChEMBL488931 N
Jmol-3D images	Image
PubChem	5281828
SMILES C/C(CC1=CC(OC)=C(Cl)C(N3C)=C1)=C\C=C\[C@@H](OC)[C@@]2(O)C[C@]([C@@H](C)[C@H]4[C@](O4)(C)[C@@H](OC([C@H](C)N(C)C(C)=O)=O)CC3=O)([H])OC(N2)=O
UNII	14083FR882 N
Properties
Chemical formula	C34H46ClN3O10
Molar mass	692.20 g/mol
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
N verify (what is: Y/N?)
Infobox references

Maitansine (INN), or maytansine (USAN), is a cytotoxic agent. It inhibits the assembly of microtubules by binding to tubulin at the rhizoxin binding site.^[1]

It is a macrolide of the ansamycin type and can be isolated from plants of the genus Maytenus.^[1]

Derivatives are known as maytansinoids.^[2]

See also

• Mertansine, a derivative

References