Mafenide

Mafenide

Systematic (IUPAC) name
4-(Aminomethyl)benzenesulfonamide
Clinical data
AHFS/Drugs.com	monograph
Routes of administration	Topical
Identifiers
CAS Registry Number	138-39-6 N
ATC code	D06BA03
PubChem	CID 3998
ChemSpider	3858 Y
UNII	58447S8P4L Y
KEGG	D02351 Y
ChEMBL	CHEMBL419 Y
Chemical data
Formula	C7H10N2O2S
Molecular mass	186.233 g/mol
SMILES O=S(=O)(c1ccc(cc1)CN)N
InChI InChI=1S/C7H10N2O2S/c8-5-6-1-3-7(4-2-6)12(9,10)11/h1-4H,5,8H2,(H2,9,10,11)  Y Key:TYMRLRRVMHJFTF-UHFFFAOYSA-N  Y
N (what is this?)  (verify)

Mafenide (INN; usually as mafenide acetate, trade name Sulfamylon) is a sulfonamide-type medication used as an antibiotic. It was approved by the FDA in 1948.

Uses

Mafenide is used to treat severe burns.^[1][2] It is used topically as an adjunctive therapy for second- and third-degree burns. It is bacteriostatic against many gram-positive and gram-negative organisms, including Pseudomonas aeruginosa. Some sources state that mafenide is more appropriate for non-facial burns, while chloramphenicol/prednisolone or bacitracin are more appropriate for facial burns.^[3]

Mechanism of action

Mafenide works by reducing the bacterial population present in the avascular tissues of burns and permits spontaneous healing of deep partial-thickness burns.

Adverse reactions

Adverse reactions can include superinfection, pain or burning upon application, rash, pruritus, tachypnea, or hyperventilation. Mafenide is metabolized to a carbonic anhydrase inhibitor, which could potentially result in metabolic acidosis.

Drug interactions

There are no significant interactions.

Contraindications

Mafenide is contraindicated in those with sulfonamide hypersensitivity or renal impairment.

Dosage

For use as adjunctive therapy for second- and third-degree burns to prevent infection, adults and children should apply topically to a thickness of approximately 1.6 mm to cleaned and debrided wound once or twice per day with a sterile gloved hand. The burned area should be covered with cream at all times.

References

External links

• Mafenide information on RxList