MYOM2
| Myomesin 2 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | MYOM2 ; TTNAP | ||||||||||||
| External IDs | OMIM: 603509 MGI: 1328358 HomoloGene: 2953 GeneCards: MYOM2 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 9172 | 17930 | |||||||||||
| Ensembl | ENSG00000036448 | ENSMUSG00000031461 | |||||||||||
| UniProt | P54296 | O55124 | |||||||||||
| RefSeq (mRNA) | NM_003970 | NM_008664 | |||||||||||
| RefSeq (protein) | NP_003961 | NP_032690 | |||||||||||
| Location (UCSC) | Chr 8: 1.99 – 2.11 Mb | Chr 8: 15.06 – 15.13 Mb | |||||||||||
| PubMed search | |||||||||||||
Myomesin-2 is a protein that in humans is encoded by the MYOM2 gene.[1]
Function
The giant protein titin, together with its associated proteins, interconnects the major structure of sarcomeres, the M bands and Z discs. The C-terminal end of the titin string extends into the M line, where it binds tightly to M-band constituents of apparent molecular masses of 190 kD and 165 kD. The predicted MYOM2 protein contains 1,465 amino acids. Like MYOM1, MYOM2 has a unique N-terminal domain followed by 12 repeat domains with strong homology to either fibronectin type III or immunoglobulin C2 domains. Protein sequence comparisons suggested that the MYOM2 protein and bovine M protein are identical.[1]
References
Further reading
- Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
- Hornemann T, Kempa S, Himmel M, Hayess K, Fürst DO, Wallimann T (2003). "Muscle-type creatine kinase interacts with central domains of the M-band proteins myomesin and M-protein". J. Mol. Biol. 332 (4): 877–87. doi:10.1016/S0022-2836(03)00921-5. PMID 12972258. Vancouver style error (help)
- van der Ven PF, Speel EJ, Albrechts JC, Ramaekers FC, Hopman AH, Fürst DO (1999). "Assignment of the human gene for endosarcomeric cytoskeletal M-protein (MYOM2) to 8p23.3". Genomics 55 (2): 253–5. doi:10.1006/geno.1998.5603. PMID 9933576. Vancouver style error (help)
- Obermann WM, van der Ven PF, Steiner F, Weber K, Fürst DO (1998). "Mapping of a Myosin-binding Domain and a Regulatory Phosphorylation Site in M-Protein, a Structural Protein of the Sarcomeric M Band". Mol. Biol. Cell 9 (4): 829–40. doi:10.1091/mbc.9.4.829. PMC 25310. PMID 9529381. Vancouver style error (help)
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Vinkemeier U, Obermann W, Weber K, Fürst DO (1994). "The globular head domain of titin extends into the center of the sarcomeric M band. cDNA cloning, epitope mapping and immunoelectron microscopy of two titin-associated proteins". J. Cell. Sci. 106 (1): 319–30. PMID 7505783. Vancouver style error (help)