MYOM1
| Myomesin 1 | |||||||||||||
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 Myomesin Domains MY9-MY11. PDB 2y23[1] | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | MYOM1 ; SKELEMIN | ||||||||||||
| External IDs | OMIM: 603508 MGI: 1341430 HomoloGene: 31196 GeneCards: MYOM1 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 8736 | 17929 | |||||||||||
| Ensembl | ENSG00000101605 | ENSMUSG00000024049 | |||||||||||
| UniProt | P52179 | Q62234 | |||||||||||
| RefSeq (mRNA) | NM_003803 | NM_001083934 | |||||||||||
| RefSeq (protein) | NP_003794 | NP_001077403 | |||||||||||
| Location (UCSC) | Chr 18: 3.07 – 3.22 Mb | Chr 17: 71.02 – 71.13 Mb | |||||||||||
| PubMed search | |||||||||||||
Myomesin-1 is a protein that in humans is encoded by the MYOM1 gene.[2][3]
The giant protein titin, together with its associated proteins, interconnects the major structure of sarcomeres, the M bands and Z discs. The C-terminal end of the titin string extends into the M line, where it binds tightly to M-band constituents of apparent molecular masses of 190 kD (myomesin 1) and 165 kD (myomesin 2). This protein, myomesin 1, like myomesin 2, titin, and other myofibrillar proteins contains structural modules with strong homology to either fibronectin type III (motif I) or immunoglobulin C2 (motif II) domains. Myomesin 1 and myomesin 2 each have a unique N-terminal region followed by 12 modules of motif I or motif II, in the arrangement II-II-I-I-I-I-I-II-II-II-II-II. The two proteins share 50% sequence identity in this repeat-containing region. The head structure formed by these 2 proteins on one end of the titin string extends into the center of the M band. The integrating structure of the sarcomere arises from muscle-specific members of the superfamily of immunoglobulin-like proteins. Alternatively spliced transcript variants encoding different isoforms have been identified.[3]
References
- ↑ Pinotsis, N.; Chatziefthimiou, S. D.; Berkemeier, F.; Beuron, F.; Mavridis, I. M.; Konarev, P. V.; Svergun, D. I.; Morris, E.; Rief, M.; Wilmanns, M. (2012). Petsko, Gregory A, ed. "Superhelical Architecture of the Myosin Filament-Linking Protein Myomesin with Unusual Elastic Properties". PLoS Biology 10 (2): e1001261. doi:10.1371/journal.pbio.1001261. PMC 3279516. PMID 22347812.
- ↑ Speel EJ, van der Ven PF, Albrechts JC, Ramaekers FC, Furst DO, Hopman AH (Jan 1999). "Assignment of the human gene for the sarcomeric M-band protein myomesin (MYOM1) to 18p11.31-p11.32". Genomics 54 (1): 184–6. doi:10.1006/geno.1998.5503. PMID 9806852.
- ↑ 3.0 3.1 "Entrez Gene: MYOM1 myomesin 1 (skelemin) 185kDa".
Further reading
- Grove BK; Kurer V; Lehner C et al. (1984). "A new 185,000-dalton skeletal muscle protein detected by monoclonal antibodies". J. Cell Biol. 98 (2): 518–24. doi:10.1083/jcb.98.2.518. PMC 2113097. PMID 6537951.
- Vinkemeier U, Obermann W, Weber K, Fürst DO (1994). "The globular head domain of titin extends into the center of the sarcomeric M band. cDNA cloning, epitope mapping and immunoelectron microscopy of two titin-associated proteins". J. Cell. Sci. 106 (1): 319–30. PMID 7505783.
- Obermann WM, Plessmann U, Weber K, Fürst DO (1995). "Purification and biochemical characterization of myomesin, a myosin-binding and titin-binding protein, from bovine skeletal muscle". Eur. J. Biochem. 233 (1): 110–5. doi:10.1111/j.1432-1033.1995.110_1.x. PMID 7588733.
- Steiner F, Weber K, Fürst DO (1999). "M band proteins myomesin and skelemin are encoded by the same gene: analysis of its organization and expression". Genomics 56 (1): 78–89. doi:10.1006/geno.1998.5682. PMID 10036188.
- Agarkova I, Auerbach D, Ehler E, Perriard JC (2000). "A novel marker for vertebrate embryonic heart, the EH-myomesin isoform". J. Biol. Chem. 275 (14): 10256–64. doi:10.1074/jbc.275.14.10256. PMID 10744711.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Porter JD; Merriam AP; Gong B et al. (2004). "Postnatal suppression of myomesin, muscle creatine kinase and the M-line in rat extraocular muscle". J. Exp. Biol. 206 (Pt 17): 3101–12. doi:10.1242/jeb.00511. PMID 12878677.
- Hornemann T; Kempa S; Himmel M et al. (2003). "Muscle-type creatine kinase interacts with central domains of the M-band proteins myomesin and M-protein". J. Mol. Biol. 332 (4): 877–87. doi:10.1016/S0022-2836(03)00921-5. PMID 12972258.
- Lange S; Himmel M; Auerbach D et al. (2005). "Dimerisation of myomesin: implications for the structure of the sarcomeric M-band". J. Mol. Biol. 345 (2): 289–98. doi:10.1016/j.jmb.2004.10.040. PMID 15571722.
- Schoenauer R; Bertoncini P; Machaidze G et al. (2005). "Myomesin is a molecular spring with adaptable elasticity". J. Mol. Biol. 349 (2): 367–79. doi:10.1016/j.jmb.2005.03.055. PMID 15890201.