MYO9B

Myosin IXB

Identifiers

MYO9B ; CELIAC4; MYR5

External IDs

OMIM: 602129 MGI: 106624 HomoloGene: 3058 GeneCards: MYO9B Gene

Gene ontology
Molecular function	• microfilament motor activity • actin binding • Rho GTPase activator activity • protein binding • calmodulin binding • ATP binding • zinc ion binding • ATPase activity • actin-dependent ATPase activity • protein homodimerization activity • ATP-dependent protein binding • ADP binding • actin filament binding
Cellular component	• ruffle • cytoplasm • cytosol • cell cortex • actin cytoskeleton • membrane • myosin complex • lamellipodium • filamentous actin • filopodium tip • perinuclear region of cytoplasm
Biological process	• monocyte chemotaxis • ATP catabolic process • small GTPase mediated signal transduction • Rho protein signal transduction • establishment of cell polarity • actin filament-based movement • ARF protein signal transduction • positive regulation of Rho GTPase activity • macrophage chemotaxis • regulation of small GTPase mediated signal transduction • lamellipodium morphogenesis
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000099331

ENSMUSG00000004677

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 19:
17.19 – 17.33 Mb

Chr 8:
71.27 – 71.36 Mb

PubMed search

Myosin-IXb is a protein that in humans is encoded by the MYO9B gene.^[1]^[2]

References

↑ Bahler M, Kehrer I, Gordon L, Stoffler HE, Olsen AS (Sep 1997). "Physical mapping of human myosin-IXB (MYO9B), the human orthologue of the rat myosin myr 5, to chromosome 19p13.1". Genomics 43 (1): 107–9. doi:10.1006/geno.1997.4776. PMID 9226381.
↑ "Entrez Gene: MYO9B myosin IXB".

Further reading

Bement WM, Hasson T, Wirth JA et al. (1994). "Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types.". Proc. Natl. Acad. Sci. U.S.A. 91 (14): 6549–53. doi:10.1073/pnas.91.14.6549. PMC 44240. PMID 8022818.
Wirth JA, Jensen KA, Post PL et al. (1997). "Human myosin-IXb, an unconventional myosin with a chimerin-like rho/rac GTPase-activating protein domain in its tail.". J. Cell. Sci. 109 (3): 653–61. PMID 8907710.
Post PL, Bokoch GM, Mooseker MS (1998). "Human myosin-IXb is a mechanochemically active motor and a GAP for rho.". J. Cell. Sci. 111 (7): 941–50. PMID 9490638.
Grewal PK, Jones AM, Maconochie M et al. (2000). "Cloning of the murine unconventional myosin gene Myo9b and identification of alternative splicing.". Gene 240 (2): 389–98. doi:10.1016/S0378-1119(99)00459-X. PMID 10580159.
Post PL, Tyska MJ, O'Connell CB et al. (2002). "Myosin-IXb is a single-headed and processive motor.". J. Biol. Chem. 277 (14): 11679–83. doi:10.1074/jbc.M111173200. PMID 11801597.
Inoue A, Saito J, Ikebe R, Ikebe M (2002). "Myosin IXb is a single-headed minus-end-directed processive motor.". Nat. Cell Biol. 4 (4): 302–6. doi:10.1038/ncb774. PMID 11901422.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Van Belzen MJ, Meijer JW, Sandkuijl LA et al. (2003). "A major non-HLA locus in celiac disease maps to chromosome 19.". Gastroenterology 125 (4): 1032–41. doi:10.1016/S0016-5085(03)01205-8. PMID 14517787.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Saeki N, Tokuo H, Ikebe M (2005). "BIG1 is a binding partner of myosin IXb and regulates its Rho-GTPase activating protein activity.". J. Biol. Chem. 280 (11): 10128–34. doi:10.1074/jbc.M413415200. PMID 15644318.
Cheng J, Kapranov P, Drenkow J et al. (2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution.". Science 308 (5725): 1149–54. doi:10.1126/science.1108625. PMID 15790807.
Monsuur AJ, de Bakker PI, Alizadeh BZ et al. (2006). "Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect.". Nat. Genet. 37 (12): 1341–4. doi:10.1038/ng1680. PMID 16282976.
Kambara T, Ikebe M (2006). "A unique ATP hydrolysis mechanism of single-headed processive myosin, myosin IX.". J. Biol. Chem. 281 (8): 4949–57. doi:10.1074/jbc.M509141200. PMID 16338935.
Nishikawa M, Nishikawa S, Inoue A et al. (2006). "A unique mechanism for the processive movement of single-headed myosin-IX.". Biochem. Biophys. Res. Commun. 343 (4): 1159–64. doi:10.1016/j.bbrc.2006.03.057. PMID 16616011.
Amundsen SS, Monsuur AJ, Wapenaar MC et al. (2006). "Association analysis of MYO9B gene polymorphisms with celiac disease in a Swedish/Norwegian cohort.". Hum. Immunol. 67 (4-5): 341–5. doi:10.1016/j.humimm.2006.03.020. PMID 16720215.
Giordano M, Marano C, Mellai M et al. (2007). "A family-based study does not confirm the association of MYO9B with celiac disease in the Italian population.". Genes Immun. 7 (7): 606–8. doi:10.1038/sj.gene.6364331. PMID 16943798.
Olsen JV, Blagoev B, Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
van Bodegraven AA, Curley CR, Hunt KA et al. (2007). "Genetic variation in myosin IXB is associated with ulcerative colitis.". Gastroenterology 131 (6): 1768–74. doi:10.1053/j.gastro.2006.09.011. PMID 17087940.
Núñez C, Márquez A, Varadé J et al. (2007). "No evidence of association of the MYO9B polymorphisms with celiac disease in the Spanish population.". Tissue Antigens 68 (6): 489–92. doi:10.1111/j.1399-0039.2006.00699.x. PMID 17176439.