MYH13
| Myosin, heavy chain 13, skeletal muscle | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | MYH13 ; MyHC-eo | ||||||||||||
| External IDs | OMIM: 603487 MGI: 1339967 HomoloGene: 55780 GeneCards: MYH13 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 8735 | 544791 | |||||||||||
| Ensembl | ENSG00000006788 | ENSMUSG00000060180 | |||||||||||
| UniProt | Q9UKX3 | B1AR69 | |||||||||||
| RefSeq (mRNA) | NM_003802 | NM_001081250 | |||||||||||
| RefSeq (protein) | NP_003793 | NP_001074719 | |||||||||||
| Location (UCSC) | Chr 17: 10.2 – 10.28 Mb | Chr 11: 67.32 – 67.37 Mb | |||||||||||
| PubMed search | |||||||||||||
Myosin-13 also known as myosin, heavy chain 13 is a protein which in humans is encoded by the MYH13 gene.[1]
Function
MYH13 is a myosin whose expression is restricted primarily to the extrinsic eye muscles which are specialized for function in eye movement.[2]
References
- ↑ Winters LM, Briggs MM, Schachat F (November 1998). "The human extraocular muscle myosin heavy chain gene (MYH13) maps to the cluster of fast and developmental myosin genes on chromosome 17". Genomics 54 (1): 188–9. doi:10.1006/geno.1998.5558. PMID 9806854.
- ↑ Weiss A, Schiaffino S, Leinwand LA (July 1999). "Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity". J. Mol. Biol. 290 (1): 61–75. doi:10.1006/jmbi.1999.2865. PMID 10388558.
Further reading
- Weiss A, McDonough D, Wertman B et al. (1999). "Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved.". Proc. Natl. Acad. Sci. U.S.A. 96 (6): 2958–63. doi:10.1073/pnas.96.6.2958. PMC 15877. PMID 10077619.
- Schachat F, Briggs MM (2002). "Phylogenetic implications of the superfast myosin in extraocular muscles.". J. Exp. Biol. 205 (Pt 15): 2189–201. PMID 12110653.
- Trynka G, Zhernakova A, Romanos J et al. (2009). "Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.". Gut 58 (8): 1078–83. doi:10.1136/gut.2008.169052. PMID 19240061.
- Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
- Schjeide BM, McQueen MB, Mullin K et al. (2009). "Assessment of Alzheimer's disease case-control associations using family-based methods.". Neurogenetics 10 (1): 19–25. doi:10.1007/s10048-008-0151-3. PMC 2841132. PMID 18830724.
- Shoeman RL, Sachse C, Höner B et al. (1993). "Cleavage of human and mouse cytoskeletal and sarcomeric proteins by human immunodeficiency virus type 1 protease. Actin, desmin, myosin, and tropomyosin.". Am. J. Pathol. 142 (1): 221–30. PMC 1886840. PMID 8424456.
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