MYH1

Myosin, heavy chain 1, skeletal muscle, adult

PDB rendering based on 1m8q.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1m8q, 1mvw, 1o18, 1o19, 1o1a, 1o1b, 1o1c, 1o1d, 1o1e, 1o1f, 1o1g

Identifiers

Symbols

MYH1 ; HEL71; MYHSA1; MYHa; MyHC-2X/D; MyHC-2x

External IDs

OMIM: 160730 MGI: 1339711 HomoloGene: 133718 GeneCards: MYH1 Gene

Gene ontology
Molecular function	• motor activity • actin binding • calmodulin binding • ATP binding
Cellular component	• muscle myosin complex • intercalated disc • A band • myosin filament • cytoplasmic ribonucleoprotein granule
Biological process	• muscle contraction • metabolic process
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 17:
10.4 – 10.42 Mb

Chr 11:
67.2 – 67.22 Mb

PubMed search

Myosin-1 is a protein that in humans is encoded by the MYH1 gene.^[1]^[2]

Myosin is a major contractile protein that converts chemical energy into mechanical energy through the hydrolysis of ATP. Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. Myosin heavy chains are encoded by a multigene family. In mammals, at least ten different myosin heavy chain (MYH) isoforms have been described from striated, smooth, and nonmuscle cells. These isoforms show expression that is spatially and temporally regulated during development.^[2]

References

↑ Leinwand LA, Saez L, McNally E, Nadal-Ginard B (Jul 1983). "Isolation and characterization of human myosin heavy chain genes". Proc Natl Acad Sci U S A 80 (12): 3716–20. doi:10.1073/pnas.80.12.3716. PMC 394121. PMID 6304733.
↑ 2.0 2.1 "Entrez Gene: MYH1 myosin, heavy chain 1, skeletal muscle, adult".

Yoon SJ, Seiler SH, Kucherlapati R, Leinwand L (1993). "Organization of the human skeletal myosin heavy chain gene cluster". Proc. Natl. Acad. Sci. U.S.A. 89 (24): 12078–82. doi:10.1073/pnas.89.24.12078. PMC 50701. PMID 1465443.
Saez L, Leinwand LA (1986). "Characterization of diverse forms of myosin heavy chain expressed in adult human skeletal muscle". Nucleic Acids Res. 14 (7): 2951–69. doi:10.1093/nar/14.7.2951. PMC 339714. PMID 2421254.
Smerdu V, Karsch-Mizrachi I, Campione M et al. (1995). "Type IIx myosin heavy chain transcripts are expressed in type IIb fibers of human skeletal muscle". Am. J. Physiol. 267 (6 Pt 1): C1723–8. PMID 7545970.
Weiss A, McDonough D, Wertman B et al. (1999). "Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved". Proc. Natl. Acad. Sci. U.S.A. 96 (6): 2958–63. doi:10.1073/pnas.96.6.2958. PMC 15877. PMID 10077619.
Weiss A, Schiaffino S, Leinwand LA (1999). "Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity". J. Mol. Biol. 290 (1): 61–75. doi:10.1006/jmbi.1999.2865. PMID 10388558.
Daugaard JR, Nielsen JN, Kristiansen S et al. (2000). "Fiber type-specific expression of GLUT4 in human skeletal muscle: influence of exercise training". Diabetes 49 (7): 1092–5. doi:10.2337/diabetes.49.7.1092. PMID 10909963.
Korfage JA, Brugman P, Van Eijden TM (2000). "Intermuscular and intramuscular differences in myosin heavy chain composition of the human masticatory muscles". J. Neurol. Sci. 178 (2): 95–106. doi:10.1016/S0022-510X(00)00372-5. PMID 11018701.
Konig S, Burkman J, Fitzgerald J et al. (2002). "Modular organization of phylogenetically conserved domains controlling developmental regulation of the human skeletal myosin heavy chain gene family". J. Biol. Chem. 277 (31): 27593–605. doi:10.1074/jbc.M203162200. PMID 11971910.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Villacé P, Marión RM, Ortín J (2004). "The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs". Nucleic Acids Res. 32 (8): 2411–20. doi:10.1093/nar/gkh552. PMC 419443. PMID 15121898.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kimura K, Wakamatsu A, Suzuki Y et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Pontén EM, Stål PS (2007). "Decreased capillarization and a shift to fast myosin heavy chain IIx in the biceps brachii muscle from young adults with spastic paresis". J. Neurol. Sci. 253 (1–2): 25–33. doi:10.1016/j.jns.2006.11.006. PMID 17196619.

PDB gallery

1m8q: Molecular Models of Averaged Rigor Crossbridges from Tomograms of Insect Flight Muscle

1mvw: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE

1o18: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE

1o19: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE

1o1a: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE

1o1b: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE

1o1c: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE

1o1d: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE

1o1e: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE

1o1f: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE

1o1g: MOLECULAR MODELS OF AVERAGED RIGOR CROSSBRIDGES FROM TOMOGRAMS OF INSECT FLIGHT MUSCLE

Proteins of the cytoskeleton

Human

Microfilaments
(ABPs)

Myofilament

Actins	A1 A2 B C1 G1 G2

Myosins	I MYO1A MYO1B MYO1C MYO1D MYO1E MYO1F MYO1G MYO1H) II MYH1 MYH2 MYH3 MYH4 MYH6 MYH7 MYH7B MYH8 MYH9 MYH10 MYH11 MYH13 MYH14 MYH15 MYH16 III MYO3A MYO3B V MYO5A MYO5B MYO5C VI MYO6 VII MYO7A MYO7B IX MYO9A MYO9B X MYO10 XV MYO15A XVIII MYO18A MYO18B LC MYL1 MYL2 MYL3 MYL4 MYL5 MYL6 MYL6B MYL7 MYL9 MYLIP MYLK MYLK2 MYLL1

Other	Tropomodulin 1 2 3 4 Troponin T 1 2 3 C 1 2 I 1 2 3 Tropomyosin 1 2 3 4 Actinin 1 2 3 4 Arp2/3 complex actin depolymerizing factors Cofilin 1 2 Destrin Gelsolin Profilin 1 2 Titin

Other

Wiskott-Aldrich syndrome protein
Fibrillin
Filamin
- FLNA
- FLNB
- FLNC
Espin
TRIOBP

IFs

Type 1/2
(Keratin,
Cytokeratin)

Epithelial keratins (soft alpha-keratins)	type I/chromosome 17 10 12 13 14 15 16 17 19 20 chromosome 12 18 none 21 type II/chromosome 12 1 2A 3 4 5 6A 6B 7 8 9

Hair keratins (hard alpha-keratins)	type I/chromosome 17 31 32 33A 33B 34 35 36 37 38 type II/chromosome 12 81 82 83 84 85 86

Ungrouped alpha	chromosome 17 23 24 25 26 27 28 39 40 chromosome 12 71 72 73 74 75 76 77 78 79 80

Not alpha	Beta-keratin

Type 3

Type 4

Type 5

Lamin A
B

Microtubules/
MAPs

Kinesins	KIF1A KIF1B KIF2A KIF2C KIF3B KIF3C KIF4A KIF4B KIF5A KIF5B KIF5C KIF6 KIF7 KIF9 KIF11 KIF12 KIF13A KIF13B KIF14 KIF15 KIF16B KIF17 KIF18A KIF18B KIF19 KIF20A KIF20B KIF21A KIF21B KIF22 KIF23 KIF24 KIF25 KIF26A KIF26B KIF27 KIFC1 KIFC2 KIFC3

Dyneins	axonemal: DNAH1 DNAH2 DNAH3 DNAH5 DNAH6 DNAH7 DNAH8 DNAH9 DNAH10 DNAH11 DNAH12 DNAH13 DNAH14 DNAH17 DNAI1 DNAI2 DNALI1 DNAL1 DNAL4 cytoplasmic: DYNC1H1 DYNC2H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC2LI1 DYNLL1 DYNLL2 DYNLRB1 DYNLRB2 DYNLT1 DYNLT3

Other	Tau protein Dynactin DCTN1 Tubulins TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA8 Stathmin Tektin TEKT1 TEKT2 TEKT3 TEKT4 TEKT5 Dynamin DNM1 DNM2 DNM3

Catenins

Membrane

Dystrophin
- Dystroglycan
Utrophin
Ankyrin
- ANK1
- ANK2
- ANK3
Spectrin
- SPTA1
- SPTAN1
- SPTB
- SPTBN1
- SPTBN2
- SPTBN4
- SPTBN5

Other

Nonhuman

See also: cytoskeletal defects

Index of cells

Description	Structure nucleus chromosome genetics Organelles peroxisome cytoskeleton centrosome epithelia cilia mitochondria Membranes proteins cell adhesions Membrane transport ion channels vesicular transport solute carrier ABC transporters ATPase oxidoreduction-driven

Disease	Structural peroxisome cytoskeleton cilia mitochondria nucleus scleroprotein Membrane channelopathy solute carrier ATPase ABC transporters other extracellular ligands cell surface receptors intracellular signalling Vesicular transport Pore-forming toxins

MYH1

References

Further reading