MXRA5
| Matrix-remodelling associated 5 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbol | MXRA5 | ||||||||||||
| External IDs | HomoloGene: 56704 GeneCards: MXRA5 Gene | ||||||||||||
| |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 25878 | n/a | |||||||||||
| Ensembl | ENSG00000101825 | n/a | |||||||||||
| UniProt | Q9NR99 | n/a | |||||||||||
| RefSeq (mRNA) | NM_015419 | n/a | |||||||||||
| RefSeq (protein) | NP_056234 | n/a | |||||||||||
| Location (UCSC) | Chr X: 3.23 – 3.26 Mb | n/a | |||||||||||
| PubMed search | n/a | ||||||||||||
Matrix-remodelling associated 5 is a protein in humans that is encoded by the MXRA5 gene.[1]
Function
This gene encodes one of the matrix-remodelling associated proteins. This protein contains 7 leucine-rich repeats and 12 immunoglobulin-like C2-type domains related to perlecan. This gene has a pseudogene on chromosome Y.[1]
Clinical relevance
Mutations in this gene have been seen frequently mutated in cases of non-small cell lung carcinoma.[2]
References
- ↑ 1.0 1.1 "Entrez Gene: Matrix-remodelling associated 5". Retrieved 2012-07-24.
- ↑ Xiong D, Li G, Li K, Xu Q, Pan Z, Ding F, Vedell P, Liu P, Cui P, Hua X, Jiang H, Yin Y, Zhu Z, Li X, Zhang B, Ma D, Wang Y, You M (July 2012). "Exome sequencing identifies MXRA5 as a novel cancer gene frequently mutated in non-small cell lung carcinoma from Chinese patients". Carcinogenesis 33 (9): 1797–805. doi:10.1093/carcin/bgs210. PMID 22696596.
Further reading
- Chondrogianni, N.; Simoes, D. D. C. M.; Franceschi, C.; Gonos, E. S. (2004). "Cloning of differentially expressed genes in skin fibroblasts from centenarians". Biogerontology 5 (6): 401–409. doi:10.1007/s10522-004-3188-1. PMID 15609104.
- Fu, G. K.; Wang, J. T.; Yang, J.; Au-Young, J.; Stuve, L. L. (2004). "Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes". Genomics 84 (1): 205–210. doi:10.1016/j.ygeno.2004.01.011. PMID 15203218.
- Zou, T. T.; Selaru, F. M.; Xu, Y.; Shustova, V.; Yin, J.; Mori, Y.; Shibata, D.; Sato, F.; Wang, S.; Olaru, A.; Deacu, E.; Liu, T. C.; Abraham, J. M.; Meltzer, S. J. (2002). "Application of cDNA microarrays to generate a molecular taxonomy capable of distinguishing between colon cancer and normal colon". Oncogene 21 (31): 4855–4862. doi:10.1038/sj.onc.1205613. PMID 12101425.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.