MUC20

Mucin 20, cell surface associated

Identifiers

MUC20 ; MUC-20

External IDs

OMIM: 610360 MGI: 2385039 HomoloGene: 17135 GeneCards: MUC20 Gene

Gene ontology
Molecular function	• glucan 1,4-alpha-glucosidase activity
Cellular component	• extracellular region • Golgi lumen • basal plasma membrane • apical plasma membrane • microvillus membrane
Biological process	• activation of MAPK activity • O-glycan processing • post-translational protein modification • cellular protein metabolic process • hepatocyte growth factor receptor signaling pathway • protein homooligomerization
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 3:
195.45 – 195.47 Mb

Chr 16:
32.78 – 32.8 Mb

PubMed search

Mucin-20 is a protein that in humans is encoded by the MUC20 gene.^[1]^[2]

References

↑ Higuchi T, Orita T, Nakanishi S, Katsuya K, Watanabe H, Yamasaki Y, Waga I, Nanayama T, Yamamoto Y, Munger W, Sun HW, Falk RJ, Jennette JC, Alcorta DA, Li H, Yamamoto T, Saito Y, Nakamura M (Jan 2004). "Molecular cloning, genomic structure, and expression analysis of MUC20, a novel mucin protein, up-regulated in injured kidney". J Biol Chem 279 (3): 1968–79. doi:10.1074/jbc.M304558200. PMID 14565953.
↑ "Entrez Gene: MUC20 mucin 20, cell surface associated".

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Nagase T, Kikuno R, Ishikawa KI et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
Dias Neto E, Correa RG, Verjovski-Almeida S et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Clark HF, Gurney AL, Abaya E et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Higuchi T, Orita T, Katsuya K et al. (2004). "MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of met.". Mol. Cell. Biol. 24 (17): 7456–68. doi:10.1128/MCB.24.17.7456-7468.2004. PMC 506992. PMID 15314156.
Suzuki Y, Yamashita R, Shirota M et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Li G, Zhang H, Lv J et al. (2006). "Tandem repeats polymorphism of MUC20 is an independent factor for the progression of immunoglobulin A nephropathy.". Am. J. Nephrol. 26 (1): 43–9. doi:10.1159/000091785. PMID 16508246.

Protein, glycoconjugate: glycoproteins and glycopeptides

Mucoproteins

Mucin	CD43 CD164 MUC1 MUC2 MUC3A MUC3B MUC4 MUC5AC MUC5B MUC6 MUC7 MUC8 MUC12 MUC13 MUC15 MUC16 MUC17 MUC19 MUC20

Other	Haptoglobin Intrinsic factor Orosomucoid Peptidoglycan Phytohaemagglutinin Ovomucin

Proteoglycans

CS/DS	Decorin Biglycan Versican

HS/CS	Testican Perlecan

CS	Chondroitin sulfate proteoglycans: Aggrecan Neurocan Brevican CD44 CSPG4 CSPG5 Platelet factor 4 Structural maintenance of chromosomes 3

KS	Fibromodulin Lumican Keratocan

HS	Syndecan 1

Other

Index of inborn errors of metabolism

Description	Metabolism Enzymes and pathways: citric acid cycle enzymes pentose phosphate intermediates glycoproteins enzymes glycosaminoglycans proteoglycan enzymes phospholipid metabolism cholesterol and steroid intermediates sphingolipids enzymes eicosanoids enzymes amino acid intermediates urea cycle enzymes nucleotide intermediates

Disorders	Citric acid cycle and electron transport chain Glycoprotein Proteoglycan Fatty-acid Phospholipid Cholesterol and steroid Eicosanoid Amino acid Purine-pyrimidine Heme metabolism Symptoms and signs

Treatment	Drugs other

Index of biochemical families

Carbohydrates	Alcohols Glycoproteins Glycosides

Lipids	Eicosanoids Fatty acids intermediates Glycerides Phospholipids Sphingolipids Steroids

Nucleic acids	Constituents intermediates

Proteins	Amino acids intermediates

Other	Tetrapyrroles intermediates

MUC20

References

Further reading