MTPN

Myotrophin

PDB rendering based on 1myo.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
3AAA

Identifiers

Symbols

MTPN ; GCDP; V-1

External IDs

OMIM: 606484 MGI: 99445 HomoloGene: 40607 GeneCards: MTPN Gene

Gene ontology
Molecular function	• protein binding
Cellular component	• nucleus • cytosol • F-actin capping protein complex • axon • perinuclear region of cytoplasm • extracellular vesicular exosome
Biological process	• regulation of translation • catecholamine metabolic process • positive regulation of macromolecule biosynthetic process • positive regulation of cardiac muscle hypertrophy • cell growth • regulation of striated muscle tissue development • cerebellar granule cell differentiation • neuron differentiation • positive regulation of cell growth • skeletal muscle tissue regeneration • positive regulation of NF-kappaB transcription factor activity • striated muscle cell differentiation • positive regulation of protein metabolic process • regulation of barbed-end actin filament capping
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 7:
135.61 – 135.66 Mb

Chr 6:
35.51 – 35.54 Mb

PubMed search

Myotrophin is a protein that in humans is encoded by the MTPN gene.^[1]^[2]

Interactions

MTPN has been shown to interact with RELA^[3] and REL.^[3]

References

↑ Mitra S, Timur AA, Gupta S, Wang Q, Sen S (July 2001). "Assignment of myotrophin to human chromosome band 7q33→q35 by in situ hybridization". Cytogenet Cell Genet 93 (1–2): 151–2. doi:10.1159/000056974. PMID 11474205.
↑ "Entrez Gene: MTPN myotrophin".
↑ 3.0 3.1 Knuefermann, Pascal; Chen Peter; Misra Arunima; Shi Shu-Ping; Abdellatif Maha; Sivasubramanian Natarajan (June 2002). "Myotrophin/V-1, a protein up-regulated in the failing human heart and in postnatal cerebellum, converts NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers". J. Biol. Chem. (United States) 277 (26): 23888–97. doi:10.1074/jbc.M202937200. ISSN 0021-9258. PMID 11971907.

Taoka M; Yamakuni T; Song SY et al. (1992). "A rat cerebellar protein containing the cdc10/SWI6 motif". Eur. J. Biochem. 207 (2): 615–20. doi:10.1111/j.1432-1033.1992.tb17088.x. PMID 1633812.
Sil P, Misono K, Sen S (1993). "Myotrophin in human cardiomyopathic heart". Circ. Res. 73 (1): 98–108. doi:10.1161/01.res.73.1.98. PMID 8508536.
Sivasubramanian N, Adhikary G, Sil PC, Sen S (1996). "Cardiac myotrophin exhibits rel/NF-kappa B interacting activity in vitro". J. Biol. Chem. 271 (5): 2812–6. doi:10.1074/jbc.271.5.2812. PMID 8576259.
Anderson KM; Berrebi-Bertrand I; Kirkpatrick RB et al. (1999). "cDNA sequence and characterization of the gene that encodes human myotrophin/V-1 protein, a mediator of cardiac hypertrophy". J. Mol. Cell. Cardiol. 31 (4): 705–19. doi:10.1006/jmcc.1998.0903. PMID 10329199.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S; Weil B; Wellenreuther R et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC; Wellenreuther R; Poustka A et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Knuefermann P; Chen P; Misra A et al. (2002). "Myotrophin/V-1, a protein up-regulated in the failing human heart and in postnatal cerebellum, converts NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers". J. Biol. Chem. 277 (26): 23888–97. doi:10.1074/jbc.M202937200. PMID 11971907.
Gupta S, Sen S (2002). "Myotrophin-kappaB DNA interaction in the initiation process of cardiac hypertrophy". Biochim. Biophys. Acta 1589 (3): 247–60. doi:10.1016/S0167-4889(02)00178-7. PMID 12031792.
Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Scherer SW; Cheung J; MacDonald JR et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Hillier LW; Fulton RS; Fulton LA et al. (2003). "The DNA sequence of human chromosome 7". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS; Wagner L; Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S; Arlt D; Huber W et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Mehrle A; Rosenfelder H; Schupp I et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Xiong Z; Liu E; Yan Y et al. (2006). "An unconventional antigen translated by a novel internal ribosome entry site elicits antitumor humoral immune reactions". J. Immunol. 177 (7): 4907–16. doi:10.4049/jimmunol.177.7.4907. PMID 16982933.
Ewing RM; Chu P; Elisma F et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

PDB gallery

1myo: SOLUTION STRUCTURE OF MYOTROPHIN, NMR, 44 STRUCTURES

2myo: SOLUTION STRUCTURE OF MYOTROPHIN, NMR, MINIMIZED AVERAGE STRUCTURE

MTPN

Interactions

References

Further reading