MTMR9
| Myotubularin related protein 9 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | MTMR9 ; C8orf9; LIP-STYX; MTMR8 | ||||||||||||
| External IDs | OMIM: 606260 MGI: 2442842 HomoloGene: 9148 GeneCards: MTMR9 Gene | ||||||||||||
| |||||||||||||
| RNA expression pattern | |||||||||||||
 | |||||||||||||
 | |||||||||||||
| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 66036 | 210376 | |||||||||||
| Ensembl | ENSG00000104643 | ENSMUSG00000035078 | |||||||||||
| UniProt | Q96QG7 | Q9Z2D0 | |||||||||||
| RefSeq (mRNA) | NM_015458 | NM_177594 | |||||||||||
| RefSeq (protein) | NP_056273 | NP_808262 | |||||||||||
| Location (UCSC) | Chr 8: 11.28 – 11.33 Mb | Chr 14: 63.52 – 63.54 Mb | |||||||||||
| PubMed search | |||||||||||||
Myotubularin-related protein 9 is a protein that in humans is encoded by the MTMR9 gene.[1][2][3][4]
Function
This gene encodes a myotubularin-related protein that is atypical to most other members of the myotubularin-related protein family because it has no dual-specificity phosphatase domain. The encoded protein contains a double-helical motif similar to the SET interaction domain, which is thought to have a role in the control of cell proliferation. In mouse, a protein similar to the encoded protein binds with MTMR7, and together they dephosphorylate phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate.[4]
Interactions
MTMR9 has been shown to interact with MTMR6.[3]
References
- ↑ Appel S, Reichwald K, Zimmermann W, Reis A, Rosenthal A, Hennies HC (Jul 2001). "Identification and localization of a new human myotubularin-related protein gene, mtmr8, on 8p22-p23". Genomics 75 (1-3): 6–8. doi:10.1006/geno.2001.6591. PMID 11472061.
- ↑ Appel S, Filter M, Reis A, Hennies HC, Bergheim A, Ogilvie E et al. (Mar 2002). "Physical and transcriptional map of the critical region for keratolytic winter erythema (KWE) on chromosome 8p22-p23 between D8S550 and D8S1759". Eur. J. Hum. Genet. 10 (1): 17–25. doi:10.1038/sj.ejhg.5200750. PMID 11896452.
- ↑ 3.0 3.1 Mochizuki Y, Majerus PW (Aug 2003). "Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9". Proc. Natl. Acad. Sci. U.S.A. 100 (17): 9768–73. doi:10.1073/pnas.1333958100. PMC 187840. PMID 12890864.
- ↑ 4.0 4.1 "Entrez Gene: MTMR9 myotubularin related protein 9".
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
- Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Wang JC, Radford DM, Holt MS, Helms C, Goate A, Brandt W et al. (1999). "Sequence-ready contig for the 1.4-cM ductal carcinoma in situ loss of heterozygosity region on chromosome 8p22-p23". Genomics 60 (1): 1–11. doi:10.1006/geno.1999.5905. PMID 10458905.
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
| |||||||||||||||||||||||||||||||