MTCH2

Mitochondrial carrier 2
Identifiers
SymbolsMTCH2 ; MIMP; SLC25A50
External IDsOMIM: 613221 MGI: 1929260 HomoloGene: 8645 IUPHAR: 2555 GeneCards: MTCH2 Gene
Orthologs
SpeciesHumanMouse
Entrez2378856428
EnsemblENSG00000109919ENSMUSG00000027282
UniProtQ9Y6C9Q791V5
RefSeq (mRNA)NM_014342NM_019758
RefSeq (protein)NP_055157NP_062732
Location (UCSC)Chr 11:
47.64 – 47.66 Mb
Chr 2:
90.85 – 90.87 Mb
PubMed search

Mitochondrial carrier homolog 2 also known as MTCH2 is a protein which in humans is encoded by the MTCH2 gene.[1][2][3][4]

Clinical significance

Variants of the MTCH2 gene may be associated with obesity.[5]

See also

References

  1. Grinberg M, Schwarz M, Zaltsman Y, Eini T, Niv H, Pietrokovski S, Gross A (June 2005). "Mitochondrial carrier homolog 2 is a target of tBID in cells signaled to die by tumor necrosis factor alpha". Mol. Cell. Biol. 25 (11): 4579–90. doi:10.1128/MCB.25.11.4579-4590.2005. PMC 1140633. PMID 15899861.
  2. Gross A (June 2005). "Mitochondrial carrier homolog 2: a clue to cracking the BCL-2 family riddle?". J. Bioenerg. Biomembr. 37 (3): 113–9. doi:10.1007/s10863-005-6222-3. PMID 16167168.
  3. Schwarz M, Andrade-Navarro MA, Gross A (May 2007). "Mitochondrial carriers and pores: key regulators of the mitochondrial apoptotic program?". Apoptosis 12 (5): 869–76. doi:10.1007/s10495-007-0748-2. PMID 17453157.
  4. Yu K, Ganesan K, Tan LK, Laban M, Wu J, Zhao XD, Li H, Leung CH, Zhu Y, Wei CL, Hooi SC, Miller L, Tan P (2008). Chang, Howard Y., ed. "A precisely regulated gene expression cassette potently modulates metastasis and survival in multiple solid cancers". PLoS Genet. 4 (7): e1000129. doi:10.1371/journal.pgen.1000129. PMC 2444049. PMID 18636107.
  5. Renström F, Payne F, Nordström A et al. (April 2009). "Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden". Hum. Mol. Genet. 18 (8): 1489–96. doi:10.1093/hmg/ddp041. PMC 2664142. PMID 19164386.

Further reading