MST1

Macrophage stimulating 1 (hepatocyte growth factor-like)

PDB rendering based on 2asu.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2ASU

Identifiers

MST1 ; D3F15S2; DNF15S2; HGFL; MSP; NF15S2

External IDs

OMIM: 142408 MGI: 96080 HomoloGene: 7360 ChEMBL: 6042 GeneCards: MST1 Gene

Gene ontology
Molecular function	• molecular_function • serine-type endopeptidase activity
Cellular component	• extracellular vesicular exosome
Biological process	• proteolysis • biological_process
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000173531

ENSMUSG00000032591

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 3:
49.72 – 49.73 Mb

Chr 9:
108.08 – 108.09 Mb

PubMed search

Hepatocyte growth factor-like protein is a protein that in humans is encoded by the MST1 gene.^[1]^[2]^[3]

References

↑ Gerber MJ, Drabkin HA, Firnhaber C, Miller YE, Scoggin CH, Smith DI (Oct 1988). "Regional localization of chromosome 3-specific DNA fragments by using a hybrid cell deletion mapping panel". Am J Hum Genet 43 (4): 442–51. PMC 1715492. PMID 2902784.
↑ Yoshimura T, Yuhki N, Wang MH, Skeel A, Leonard EJ (Aug 1993). "Cloning, sequencing, and expression of human macrophage stimulating protein (MSP, MST1) confirms MSP as a member of the family of kringle proteins and locates the MSP gene on chromosome 3". J Biol Chem 268 (21): 15461–8. PMID 8393443.
↑ "Entrez Gene: MST1 macrophage stimulating 1 (hepatocyte growth factor-like)".

Further reading

Han S, Stuart LA, Degen SJ (1991). "Characterization of the DNF15S2 locus on human chromosome 3: identification of a gene coding for four kringle domains with homology to hepatocyte growth factor.". Biochemistry 30 (40): 9768–80. doi:10.1021/bi00104a029. PMID 1655021.
Skeel A, Yoshimura T, Showalter SD et al. (1991). "Macrophage stimulating protein: purification, partial amino acid sequence, and cellular activity.". J. Exp. Med. 173 (5): 1227–34. doi:10.1084/jem.173.5.1227. PMC 2118857. PMID 1827141.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Waltz SE, Gould FK, Air EL et al. (1996). "Hepatocyte nuclear factor-4 is responsible for the liver-specific expression of the gene coding for hepatocyte growth factor-like protein". J. Biol. Chem. 271 (15): 9024–32. doi:10.1074/jbc.271.15.9024. PMID 8621550.
Creasy CL, Ambrose DM, Chernoff J (1996). "The Ste20-like protein kinase, Mst1, dimerizes and contains an inhibitory domain". J. Biol. Chem. 271 (35): 21049–53. doi:10.1074/jbc.271.35.21049. PMID 8702870.
Sakamoto O, Iwama A, Amitani R et al. (1997). "Role of macrophage-stimulating protein and its receptor, RON tyrosine kinase, in ciliary motility". J. Clin. Invest. 99 (4): 701–9. doi:10.1172/JCI119214. PMC 507853. PMID 9045873.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Yoshikawa W, Hara H, Takehara T et al. (1999). "Characterization of free alpha- and beta-chains of recombinant macrophage-stimulating protein". Arch. Biochem. Biophys. 363 (2): 356–60. doi:10.1006/abbi.1998.1090. PMID 10068459.
Degen SJ, McDowell SA, Waltz SE et al. (2000). "Structure of the human D1F15S1A locus: a chromosome 1 locus with 97% identity to the chromosome 3 gene coding for hepatocyte growth factor-like protein". DNA Seq. 8 (6): 409–13. doi:10.3109/10425179809020903. PMID 10728827.
Skeel A, Leonard EJ (2001). "alpha 1-Antichymotrypsin is the human plasma inhibitor of macrophage ectoenzymes that cleave pro-macrophage stimulating protein". J. Biol. Chem. 276 (24): 21932–7. doi:10.1074/jbc.M100652200. PMID 11274154.
Rampino T, Collesi C, Gregorini M et al. (2002). "Macrophage-stimulating protein is produced by tubular cells and activates mesangial cells". J. Am. Soc. Nephrol. 13 (3): 649–57. PMID 11856768.
Zhou YQ, Chen YQ, Fisher JH, Wang MH (2002). "Activation of the RON receptor tyrosine kinase by macrophage-stimulating protein inhibits inducible cyclooxygenase-2 expression in murine macrophages". J. Biol. Chem. 277 (41): 38104–10. doi:10.1074/jbc.M206167200. PMID 12177064.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Santoro MM, Gaudino G, Marchisio PC (2003). "The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration". Dev. Cell 5 (2): 257–71. doi:10.1016/S1534-5807(03)00201-6. PMID 12919677.
Angeloni D, Danilkovitch-Miagkova A, Miagkov A et al. (2004). "The soluble sema domain of the RON receptor inhibits macrophage-stimulating protein-induced receptor activation". J. Biol. Chem. 279 (5): 3726–32. doi:10.1074/jbc.M309342200. PMID 14597639.
Matsuzaki S, Canis M, Pouly JL et al. (2005). "The macrophage stimulating protein/RON system: a potential novel target for prevention and treatment of endometriosis". Mol. Hum. Reprod. 11 (5): 345–9. doi:10.1093/molehr/gah162. PMID 15764806.
Zalcenstein A, Weisz L, Stambolsky P et al. (2006). "Repression of the MSP/MST-1 gene contributes to the antiapoptotic gain of function of mutant p53". Oncogene 25 (3): 359–69. doi:10.1038/sj.onc.1209061. PMID 16170349.
Liu T, Qian WJ, Gritsenko MA et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.

PDB gallery

2asu: Crystal Structure of the beta-chain of HGFl/MSP