MSRA (gene)

Methionine sulfoxide reductase A

Identifiers

MSRA ; PMSR

External IDs

OMIM: 601250 MGI: 106916 HomoloGene: 5812 GeneCards: MSRA Gene

Gene ontology
Molecular function	• peptide-methionine (S)-S-oxide reductase activity
Cellular component	• nucleus • mitochondrion • membrane • extracellular vesicular exosome
Biological process	• cellular protein modification process • methionine metabolic process • response to oxidative stress • protein repair • oxidation-reduction process
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000175806

ENSMUSG00000054733

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 8:
9.91 – 10.29 Mb

Chr 14:
64.12 – 64.46 Mb

PubMed search

Peptide methionine sulfoxide reductase is an enzyme that in humans is encoded by the MSRA gene.^[1]^[2]

Function

This protein is ubiquitous and highly conserved. It carries out the enzymatic reduction of methionine sulfoxide to methionine. Human and animal studies have shown the highest levels of expression in kidney and liver. Its proposed function is the repair of oxidative damage to proteins to restore biological activity.^[2]

Clinical significance

Deletion of this gene has been associated with insulin resistance in mice.^[3]

References

↑ Kuschel L, Hansel A, Schonherr R, Weissbach H, Brot N, Hoshi T, Heinemann SH (Sep 1999). "Molecular cloning and functional expression of a human peptide methionine sulfoxide reductase (hMsrA)". FEBS Lett 456 (1): 17–21. doi:10.1016/S0014-5793(99)00917-5. PMID 10452521.
↑ 2.0 2.1 "Entrez Gene: MSRA methionine sulfoxide reductase A".
↑ Styskal JL, Nwagwu FA, Watkins YN, Liang H, Richardson A, Musi N, Salmon AB (October 2012). "Methionine sulfoxide reductase a affects insulin resistance by protecting insulin receptor function". Free Radic. Biol. Med. 56: 123–32. doi:10.1016/j.freeradbiomed.2012.10.544. PMID 23089224.

See also

MSRB2
Methionine oxidation
SEPX1

Further reading

Hansel A, Heinemann SH, Hoshi T (2005). "Heterogeneity and function of mammalian MSRs: enzymes for repair, protection and regulation.". Biochim. Biophys. Acta 1703 (2): 239–47. doi:10.1016/j.bbapap.2004.09.010. PMID 15680232.
Moskovitz J, Jenkins NA, Gilbert DJ et al. (1996). "Chromosomal localization of the mammalian peptide-methionine sulfoxide reductase gene and its differential expression in various tissues.". Proc. Natl. Acad. Sci. U.S.A. 93 (8): 3205–8. doi:10.1073/pnas.93.8.3205. PMC 39583. PMID 8622914.
Hansel A, Kuschel L, Hehl S et al. (2002). "Mitochondrial targeting of the human peptide methionine sulfoxide reductase (MSRA), an enzyme involved in the repair of oxidized proteins.". FASEB J. 16 (8): 911–3. doi:10.1096/fj.01-0737fje. PMID 12039877.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Vougier S, Mary J, Friguet B (2003). "Subcellular localization of methionine sulphoxide reductase A (MsrA): evidence for mitochondrial and cytosolic isoforms in rat liver cells.". Biochem. J. 373 (Pt 2): 531–7. doi:10.1042/BJ20030443. PMC 1223498. PMID 12693988.
Picot CR, Perichon M, Cintrat JC et al. (2004). "The peptide methionine sulfoxide reductases, MsrA and MsrB (hCBS-1), are downregulated during replicative senescence of human WI-38 fibroblasts.". FEBS Lett. 558 (1-3): 74–8. doi:10.1016/S0014-5793(03)01530-8. PMID 14759519.
Kantorow M, Hawse JR, Cowell TL et al. (2004). "Methionine sulfoxide reductase A is important for lens cell viability and resistance to oxidative stress.". Proc. Natl. Acad. Sci. U.S.A. 101 (26): 9654–9. doi:10.1073/pnas.0403532101. PMC 470730. PMID 15199188.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
De Luca A, Sacchetta P, Di Ilio C, Favaloro B (2006). "Identification and analysis of the promoter region of the human methionine sulphoxide reductase A gene.". Biochem. J. 393 (Pt 1): 321–9. doi:10.1042/BJ20050973. PMC 1383691. PMID 16162094.
Picot CR, Petropoulos I, Perichon M et al. (2006). "Overexpression of MsrA protects WI-38 SV40 human fibroblasts against H2O2-mediated oxidative stress.". Free Radic. Biol. Med. 39 (10): 1332–41. doi:10.1016/j.freeradbiomed.2005.06.017. PMID 16257642.
Lee JW, Gordiyenko NV, Marchetti M et al. (2006). "Gene structure, localization and role in oxidative stress of methionine sulfoxide reductase A (MSRA) in the monkey retina.". Exp. Eye Res. 82 (5): 816–27. doi:10.1016/j.exer.2005.10.003. PMC 2825745. PMID 16364291.
Schallreuter KU, Rübsam K, Chavan B et al. (2006). "Functioning methionine sulfoxide reductases A and B are present in human epidermal melanocytes in the cytosol and in the nucleus.". Biochem. Biophys. Res. Commun. 342 (1): 145–52. doi:10.1016/j.bbrc.2006.01.124. PMID 16480945.
Lei KF, Wang YF, Zhu XQ et al. (2007). "Identification of MSRA gene on chromosome 8p as a candidate metastasis suppressor for human hepatitis B virus-positive hepatocellular carcinoma.". BMC Cancer 7: 172. doi:10.1186/1471-2407-7-172. PMC 2000900. PMID 17784942.