MSH5
| MutS homolog 5 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | MSH5 ; G7; MUTSH5; NG23 | ||||||||||||
| External IDs | OMIM: 603382 MGI: 1329021 HomoloGene: 8415 GeneCards: MSH5 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 4439 | 17687 | |||||||||||
| Ensembl | ENSG00000204410 | ENSMUSG00000007035 | |||||||||||
| UniProt | O43196 | Q9QUM7 | |||||||||||
| RefSeq (mRNA) | NM_002441 | NM_001146215 | |||||||||||
| RefSeq (protein) | NP_002432 | NP_001139687 | |||||||||||
| Location (UCSC) | Chr 6: 31.71 – 31.73 Mb | Chr 17: 35.03 – 35.05 Mb | |||||||||||
| PubMed search | |||||||||||||
MutS protein homolog 5 is a protein that in humans is encoded by the MSH5 gene.[1][2][3][4]
This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair or meiotic recombination processes. This protein is similar to a Saccharomyces cerevisiae protein that participates in meiotic segregation fidelity and crossing-over. This protein forms heterooligomers with another member of this family, mutS homolog 4. Alternative splicing results in four transcript variants encoding three different isoforms.[4]
Interactions
MSH5 has been shown to interact with MSH4.[2][5][6]
References
- ↑ Her C, Doggett NA (May 1999). "Cloning, structural characterization, and chromosomal localization of the human orthologue of Saccharomyces cerevisiae MSH5 gene". Genomics 52 (1): 50–61. doi:10.1006/geno.1998.5374. PMID 9740671.
- ↑ 2.0 2.1 Winand NJ, Panzer JA, Kolodner RD (December 1998). "Cloning and characterization of the human and Caenorhabditis elegans homologs of the Saccharomyces cerevisiae MSH5 gene". Genomics 53 (1): 69–80. doi:10.1006/geno.1998.5447. PMID 9787078.
- ↑ Snowden T, Shim KS, Schmutte C, Acharya S, Fishel R (December 2007). "hMSH4-hMSH5 adenosine nucleotide processing and interactions with homologous recombination machinery". J Biol Chem 283 (1): 145–54. doi:10.1074/jbc.M704060200. PMC 2841433. PMID 17977839.
- ↑ 4.0 4.1 "Entrez Gene: MSH5 mutS homolog 5 (E. coli)".
- ↑ Her, Chengtao; Wu Xiling; Griswold Michael D; Zhou Feng (February 2003). "Human MutS homologue MSH4 physically interacts with von Hippel-Lindau tumor suppressor-binding protein 1". Cancer Res. (United States) 63 (4): 865–72. ISSN 0008-5472. PMID 12591739.
- ↑ Bocker, T; Barusevicius A, Snowden T, Rasio D, Guerrette S, Robbins D, Schmidt C, Burczak J, Croce C M, Copeland T, Kovatich A J, Fishel R (February 1999). "hMSH5: a human MutS homologue that forms a novel heterodimer with hMSH4 and is expressed during spermatogenesis". Cancer Res. (UNITED STATES) 59 (4): 816–22. ISSN 0008-5472. PMID 10029069.
Further reading
- Her C, Zhao N, Wu X, Tompkins JD (2007). "MutS homologues hMSH4 and hMSH5: diverse functional implications in humans.". Front. Biosci. 12: 905–11. doi:10.2741/2112. PMID 17127347.
- Sargent CA, Dunham I, Campbell RD (1989). "Identification of multiple HTF-island associated genes in the human major histocompatibility complex class III region.". EMBO J. 8 (8): 2305–12. PMC 401163. PMID 2477242.
- Albertella MR, Jones H, Thomson W et al. (1997). "Localization of eight additional genes in the human major histocompatibility complex, including the gene encoding the casein kinase II beta subunit (CSNK2B).". Genomics 36 (2): 240–51. doi:10.1006/geno.1996.0459. PMID 8812450.
- Edelmann W, Cohen PE, Kneitz B et al. (1999). "Mammalian MutS homologue 5 is required for chromosome pairing in meiosis.". Nat. Genet. 21 (1): 123–7. doi:10.1038/5075. PMID 9916805.
- Bocker T, Barusevicius A, Snowden T et al. (1999). "hMSH5: a human MutS homologue that forms a novel heterodimer with hMSH4 and is expressed during spermatogenesis.". Cancer Res. 59 (4): 816–22. PMID 10029069.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Mungall AJ, Palmer SA, Sims SK et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Xie T, Rowen L, Aguado B et al. (2004). "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.". Genome Res. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMC 403804. PMID 14656967.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Anderson NL, Polanski M, Pieper R et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources.". Mol. Cell Proteomics 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
- Snowden T, Acharya S, Butz C et al. (2004). "hMSH4-hMSH5 recognizes Holliday Junctions and forms a meiosis-specific sliding clamp that embraces homologous chromosomes.". Mol. Cell 15 (3): 437–51. doi:10.1016/j.molcel.2004.06.040. PMID 15304223.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Yi W, Wu X, Lee TH et al. (2005). "Two variants of MutS homolog hMSH5: prevalence in humans and effects on protein interaction.". Biochem. Biophys. Res. Commun. 332 (2): 524–32. doi:10.1016/j.bbrc.2005.04.154. PMID 15907804.
- Lee TH, Yi W, Griswold MD et al. (2006). "Formation of hMSH4-hMSH5 heterocomplex is a prerequisite for subsequent GPS2 recruitment.". DNA Repair (Amst.) 5 (1): 32–42. doi:10.1016/j.dnarep.2005.07.004. PMID 16122992.
- Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Sekine H, Ferreira RC, Pan-Hammarström Q et al. (2007). "Role for Msh5 in the regulation of Ig class switch recombination.". Proc. Natl. Acad. Sci. U.S.A. 104 (17): 7193–8. doi:10.1073/pnas.0700815104. PMC 1855370. PMID 17409188.
- Szafranski K, Schindler S, Taudien S et al. (2007). "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns.". Genome Biology 8 (8): R154. doi:10.1186/gb-2007-8-8-r154. PMC 2374985. PMID 17672918.