MRVI1

Murine retrovirus integration site 1 homolog
Identifiers
SymbolsMRVI1 ; IRAG; JAW1L
External IDsOMIM: 604673 MGI: 1338023 HomoloGene: 4425 GeneCards: MRVI1 Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez1033517540
EnsemblENSG00000072952ENSMUSG00000005611
UniProtQ9Y6F6Q9WUX5
RefSeq (mRNA)NM_001098579NM_010826
RefSeq (protein)NP_001092049NP_034956
Location (UCSC)Chr 11:
10.59 – 10.72 Mb		Chr 7:
110.87 – 110.98 Mb
PubMed search

Protein MRVI1 is a protein that in humans is encoded by the MRVI1 gene.[1][2]

Function

This gene is similar to a mouse putative tumor suppressor gene that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is downregulated during myeloid differentiation. Therefore, this gene may be a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcripts have been found for this gene, however, the full-length nature of some variants has not been determined. Of the two characterized variants which encode different isoforms, one initiates translation at a non-AUG start site.[2]

Interactions

MRVI1 has been shown to interact with ITPR1[3] and PRKG1.[3][4]

References

  1. ↑ Shaughnessy JD, Largaespada DA, Tian E, Fletcher CF, Cho BC, Vyas P et al. (June 1999). "Mrvi1, a common MRV integration site in BXH2 myeloid leukemias, encodes a protein with homology to a lymphoid-restricted membrane protein Jaw1". Oncogene 18 (12): 2069–84. doi:10.1038/sj.onc.1202419. PMID 10321731.
  2. ↑ 2.0 2.1 "Entrez Gene: MRVI1 murine retrovirus integration site 1 homolog".
  3. ↑ 3.0 3.1 Schlossmann J, Ammendola A, Ashman K, Zong X, Huber A, Neubauer G et al. (March 2000). "Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta". Nature 404 (6774): 197–201. doi:10.1038/35004606. PMID 10724174.
  4. ↑ Ammendola A, Geiselhöringer A, Hofmann F, Schlossmann J (June 2001). "Molecular determinants of the interaction between the inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate (IRAG) and cGMP kinase Ibeta". J. Biol. Chem. 276 (26): 24153–9. doi:10.1074/jbc.M101530200. PMID 11309393. Vancouver style error (help)

Further reading

  • Adams MD, Dubnick M, Kerlavage AR, Moreno R, Kelley JM, Utterback TR et al. (1992). "Sequence identification of 2,375 human brain genes". Nature 355 (6361): 632–4. doi:10.1038/355632a0. PMID 1538749.
  • Baltensperger K, Chiesi M, Carafoli E (1990). "Substrates of cGMP kinase in vascular smooth muscle and their role in the relaxation process". Biochemistry 29 (41): 9753–60. doi:10.1021/bi00493a035. PMID 2271613.
  • Schlossmann J, Ammendola A, Ashman K, Zong X, Huber A, Neubauer G et al. (2000). "Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta". Nature 404 (6774): 197–201. doi:10.1038/35004606. PMID 10724174.
  • Ammendola A, Geiselhöringer A, Hofmann F, Schlossmann J (2001). "Molecular determinants of the interaction between the inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate (IRAG) and cGMP kinase Ibeta". J. Biol. Chem. 276 (26): 24153–9. doi:10.1074/jbc.M101530200. PMID 11309393. Vancouver style error (help)
  • Koller A, Schlossmann J, Ashman K, Uttenweiler-Joseph S, Ruth P, Hofmann F (2003). "Association of phospholamban with a cGMP kinase signaling complex". Biochem. Biophys. Res. Commun. 300 (1): 155–60. doi:10.1016/S0006-291X(02)02799-7. PMID 12480535.
  • Fritsch RM, Saur D, Kurjak M, Oesterle D, Schlossmann J, Geiselhöringer A et al. (2004). "InsP3R-associated cGMP kinase substrate (IRAG) is essential for nitric oxide-induced inhibition of calcium signaling in human colonic smooth muscle". J. Biol. Chem. 279 (13): 12551–9. doi:10.1074/jbc.M313365200. PMID 14729908. Vancouver style error (help)
  • Casteel DE, Boss GR, Pilz RB (2005). "Identification of the interface between cGMP-dependent protein kinase Ibeta and its interaction partners TFII-I and IRAG reveals a common interaction motif". J. Biol. Chem. 280 (46): 38211–8. doi:10.1074/jbc.M507021200. PMID 16166082.
  • Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Antl M, von Brühl ML, Eiglsperger C, Werner M, Konrad I, Kocher T et al. (2007). "IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation". Blood 109 (2): 552–9. doi:10.1182/blood-2005-10-026294. PMID 16990611. Vancouver style error (help)

External links