MPST
| Mercaptopyruvate sulfurtransferase | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | MPST ; MST; TST2 | ||||||||||||
| External IDs | OMIM: 602496 MGI: 2179733 HomoloGene: 31942 IUPHAR: 1446 GeneCards: MPST Gene | ||||||||||||
| EC number | 2.8.1.2 | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 4357 | 246221 | |||||||||||
| Ensembl | ENSG00000128309 | ENSMUSG00000071711 | |||||||||||
| UniProt | P25325 | D3YYT8 | |||||||||||
| RefSeq (mRNA) | NM_001013436 | NM_001162492 | |||||||||||
| RefSeq (protein) | NP_001013454 | NP_001155964 | |||||||||||
| Location (UCSC) | Chr 22: 37.42 – 37.43 Mb | Chr 15: 78.41 – 78.41 Mb | |||||||||||
| PubMed search | |||||||||||||
3-mercaptopyruvate sulfurtransferase is an enzyme that in humans is encoded by the MPST gene.[1][2]
This gene encodes a protein which can function as a monomer or as a disulfide-linked homodimer and which catalyzes the transfer of a sulfur ion from 3-mercaptopyruvate to cyanide or other thiol compounds. It may be involved in cyanide degradation and in thiosulfate biosynthesis. The encoded cytoplasmic protein is a member of the rhodanese family but is not rhodanese itself, which is a mitochondrial protein. Alternatively spliced transcript variants encoding the same protein have been identified.[2]
References
- ↑ Pallini R, Guazzi GC, Cannella C, Cacace MG (Dec 1991). "Cloning and sequence analysis of the human liver rhodanese: comparison with the bovine and chicken enzymes". Biochem Biophys Res Commun 180 (2): 887–93. doi:10.1016/S0006-291X(05)81148-9. PMID 1953758.
- ↑ 2.0 2.1 "Entrez Gene: MPST mercaptopyruvate sulfurtransferase".
Further reading
- Billaut-Laden I, Rat E, Allorge D et al. (2006). "Evidence for a functional genetic polymorphism of the human mercaptopyruvate sulfurtransferase (MPST), a cyanide detoxification enzyme.". Toxicol. Lett. 165 (2): 101–11. doi:10.1016/j.toxlet.2006.02.002. PMID 16545926.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Collins JE, Wright CL, Edwards CA et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome.". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Dunham I, Shimizu N, Roe BA et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
- Aita N, Ishii K, Akamatsu Y et al. (1997). "Cloning and expression of human liver rhodanese cDNA.". Biochem. Biophys. Res. Commun. 231 (1): 56–60. doi:10.1006/bbrc.1996.6046. PMID 9070219.