MOBKL3
| MOB family member 4, phocein | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | MOB4 ; 2C4D; MOB1; MOB3; MOBKL3; PHOCN; PREI3 | ||||||||||||
| External IDs | OMIM: 609361 MGI: 104899 HomoloGene: 9116 GeneCards: MOB4 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 25843 | 19070 | |||||||||||
| Ensembl | ENSG00000115540 | ENSMUSG00000025979 | |||||||||||
| UniProt | Q9Y3A3 | Q6PEB6 | |||||||||||
| RefSeq (mRNA) | NM_001100819 | NM_025283 | |||||||||||
| RefSeq (protein) | NP_001094289 | NP_079559 | |||||||||||
| Location (UCSC) | Chr 2: 198.37 – 198.42 Mb | Chr 1: 55.13 – 55.15 Mb | |||||||||||
| PubMed search | |||||||||||||
Mps one binder kinase activator-like 3 is an enzyme that in humans is encoded by the MOBKL3 gene.[1][2][3][4]
This gene was identified based on its similarity with the mouse counterpart. Studies of the mouse counterpart suggest that the expression of this gene may be regulated during oocyte maturation and preimplantation following zygotic gene activation. Alternatively spliced transcript variants encoding distinct isoforms have been observed.[4]
Interactions
MOBKL3 has been shown to interact with STK25,[5] PDCD10,[5] CTTNBP2,[5] TRAF3IP3,[5] STRN3,[5] STK24,[5][6] PPP2CA,[5] RP6-213H19.1,[5] STRN,[5] CTTNBP2NL[5] and FAM40A.[5]
References
- ↑ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
- ↑ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- ↑ Moreno CS, Lane WS, Pallas DC (Jun 2001). "A mammalian homolog of yeast MOB1 is both a member and a putative substrate of striatin family-protein phosphatase 2A complexes". J Biol Chem 276 (26): 24253–60. doi:10.1074/jbc.M102398200. PMC 3503316. PMID 11319234.
- ↑ 4.0 4.1 "Entrez Gene: PREI3 preimplantation protein 3".
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 5.8 5.9 5.10 Goudreault, Marilyn; D'Ambrosio Lisa M, Kean Michelle J, Mullin Michael J, Larsen Brett G, Sanchez Amy, Chaudhry Sidharth, Chen Ginny I, Sicheri Frank, Nesvizhskii Alexey I, Aebersold Ruedi, Raught Brian, Gingras Anne-Claude (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Mol. Cell Proteomics (United States) 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.
- ↑ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Further reading
- Kawai J, Shinagawa A, Shibata K et al. (2001). "Functional annotation of a full-length mouse cDNA collection.". Nature 409 (6821): 685–90. doi:10.1038/35055500. PMID 11217851.
- Baillat G, Gaillard S, Castets F, Monneron A (2002). "Interactions of phocein with nucleoside-diphosphate kinase, Eps15, and Dynamin I.". J. Biol. Chem. 277 (21): 18961–6. doi:10.1074/jbc.M108818200. PMID 11872741.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Stelzl U, Worm U, Lalowski M et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
- Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Ewing RM, Chu P, Elisma F et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.