MOBKL1B

MOB kinase activator 1A

PDB rendering based on 1pi1.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1PI1, 4JIZ

Identifiers

MOB1A ; C2orf6; MATS1; MOB1; MOBK1B; MOBKL1B; Mob4B

External IDs

OMIM: 609281 MGI: 2442631 HomoloGene: 10076 GeneCards: MOB1A Gene

Gene ontology
Molecular function	• protein binding • metal ion binding
Cellular component	• cytosol
Biological process	• hippo signaling cascade
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000114978

ENSMUSG00000043131

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 2:
74.38 – 74.41 Mb

Chr 6:
83.33 – 83.34 Mb

PubMed search

Mps one binder kinase activator-like 1B is an enzyme that in humans is encoded by the MOBKL1B gene.^[1]^[2]

References

↑ Moreno CS, Lane WS, Pallas DC (Jun 2001). "A mammalian homolog of yeast MOB1 is both a member and a putative substrate of striatin family-protein phosphatase 2A complexes". J Biol Chem 276 (26): 24253–60. doi:10.1074/jbc.M102398200. PMC 3503316. PMID 11319234.
↑ "Entrez Gene: MOBK1B MOB1, Mps One Binder kinase activator-like 1B (yeast)".

Further reading

Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gevaert K, Goethals M, Martens L et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
Stavridi ES, Harris KG, Huyen Y et al. (2004). "Crystal structure of a human Mob1 protein: toward understanding Mob-regulated cell cycle pathways". Structure 11 (9): 1163–70. doi:10.1016/S0969-2126(03)00182-5. PMID 12962634.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Bichsel SJ, Tamaskovic R, Stegert MR, Hemmings BA (2005). "Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein". J. Biol. Chem. 279 (34): 35228–35. doi:10.1074/jbc.M404542200. PMID 15197186.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Lai ZC, Wei X, Shimizu T et al. (2005). "Control of cell proliferation and apoptosis by mob as tumor suppressor, mats". Cell 120 (5): 675–85. doi:10.1016/j.cell.2004.12.036. PMID 15766530.
Hillier LW, Graves TA, Fulton RS et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Ewing RM, Chu P, Elisma F et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Kosaka Y, Mimori K, Tanaka F et al. (2007). "Clinical significance of the loss of MATS1 mRNA expression in colorectal cancer". Int. J. Oncol. 31 (2): 333–8. doi:10.3892/ijo.31.2.333. PMID 17611689.

PDB gallery

1pi1: Crystal structure of a human Mob1 protein; toward understanding Mob-regulated cell cycle pathways.

1r3b: Solution structure of xenopus laevis Mob1