MOBKL1A

MOB kinase activator 1B

PDB rendering based on 1pi1.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1pi1, 1r3b

Identifiers

Symbols

MOB1B ; MATS2; MOB4A; MOBKL1A

External IDs

OMIM: 609282 MGI: 1915723 HomoloGene: 61676 GeneCards: MOB1B Gene

Gene ontology
Molecular function	• protein binding • kinase activator activity • kinase binding • metal ion binding
Cellular component	• nucleus • cytoplasm • cytosol
Biological process	• hippo signaling cascade • positive regulation of phosphorylation • protein autophosphorylation
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 4:
71.77 – 71.89 Mb

Chr 5:
88.72 – 88.76 Mb

PubMed search

Mps one binder kinase activator-like 1A, also known as Mob1 homolog 1A, is a protein that in humans is encoded by the MOBKL1A gene.^[1]^[2]

Function

The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation.^[1]

References

↑ 1.0 1.1 "Entrez Gene: MOB1".
↑ Devroe E, Erdjument-Bromage H, Tempst P, Silver PA (June 2004). "Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases". J. Biol. Chem. 279 (23): 24444–51. doi:10.1074/jbc.M401999200. PMID 15067004.

Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Bichsel SJ, Tamaskovic R, Stegert MR, Hemmings BA (2004). "Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein.". J. Biol. Chem. 279 (34): 35228–35. doi:10.1074/jbc.M404542200. PMID 15197186.
Strausberg RL, Feingold EA, Grouse LH et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Chow A, Hao Y, Yang X (2010). "Molecular characterization of human homologs of yeast MOB1.". Int. J. Cancer 126 (9): 2079–89. doi:10.1002/ijc.24878. PMID 19739119.

PDB gallery

1r3b: Solution structure of xenopus laevis Mob1

1pi1: Crystal structure of a human Mob1 protein; toward understanding Mob-regulated cell cycle pathways.

Signaling pathway: Hippo signaling pathway

Receptor

FAT4

Adaptor protein

Kinase

Transcription factor

YAP1
TAZ

Other/unknown

RASSF1

Index of signal transduction

Description	Intercellular neuropeptides growth factors cytokines hormones Cell surface receptors ligand-gated enzyme-linked G protein-coupled immunoglobulin superfamily integrins neuropeptide growth factor cytokine Intracellular adaptor proteins GTP-binding MAP kinase Calcium signaling Lipid signaling Pathways hedgehog Wnt TGF beta MAPK ERK notch JAK-STAT apoptosis hippo TLR

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

MOBKL1A

Function

See also

References

Further reading