MMP21
| Matrix metallopeptidase 21 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | MMP21 ; MMP-21 | ||||||||||||
| External IDs | OMIM: 608416 MGI: 2664387 HomoloGene: 17519 IUPHAR: 1644 GeneCards: MMP21 Gene | ||||||||||||
| EC number | 3.4.24.- | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 118856 | 214766 | |||||||||||
| Ensembl | ENSG00000154485 | ENSMUSG00000030981 | |||||||||||
| UniProt | Q8N119 | Q8K3F2 | |||||||||||
| RefSeq (mRNA) | NM_147191 | NM_152944 | |||||||||||
| RefSeq (protein) | NP_671724 | NP_694423 | |||||||||||
| Location (UCSC) | Chr 10: 127.46 – 127.46 Mb | Chr 7: 133.67 – 133.68 Mb | |||||||||||
| PubMed search | |||||||||||||
Matrix metalloproteinase-21 (MMP-21) is an enzyme that in humans is encoded by the MMP21 gene.[1][2]
Function
This gene encodes a member of the matrix metalloproteinase family. Proteins in this family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction, and tissue remodeling,and disease processes, such as asthma and metastasis. The encoded protein may play an important role in embryogenesis, particularly in neuronal cells, as well as in lymphocyte development and survival.[2]
References
- ↑ Marchenko GN, Strongin AY (Mar 2001). "MMP-28, a new human matrix metalloproteinase with an unusual cysteine-switch sequence is widely expressed in tumors". Gene 265 (1–2): 87–93. doi:10.1016/S0378-1119(01)00360-2. PMID 11255011.
- ↑ 2.0 2.1 "Entrez Gene: MMP21 matrix metallopeptidase 21".
Further reading
- Brinckerhoff CE, Matrisian LM (2002). "Matrix metalloproteinases: a tail of a frog that became a prince". Nat. Rev. Mol. Cell Biol. 3 (3): 207–14. doi:10.1038/nrm763. PMID 11994741.
- Bister V, Skoog T, Virolainen S et al. (2008). "Increased expression of matrix metalloproteinases-21 and -26 and TIMP-4 in pancreatic adenocarcinoma". Mod. Pathol. 20 (11): 1128–40. doi:10.1038/modpathol.3800956. PMID 17873896.
- Skoog T, Ahokas K, Orsmark C et al. (2006). "MMP-21 is expressed by macrophages and fibroblasts in vivo and in culture". Exp. Dermatol. 15 (10): 775–83. doi:10.1111/j.1600-0625.2006.00460.x. PMID 16984259.
- Ahokas K, Karjalainen-Lindsberg ML, Sihvo E et al. (2006). "Matrix metalloproteinases 21 and 26 are differentially expressed in esophageal squamous cell cancer". Tumour Biol. 27 (3): 133–41. doi:10.1159/000092774. PMID 16641547.
- Shagisultanova EI, Novikova IA, Sidorenko YS et al. (2004). "The matrix metalloproteinase-21 gene 572C/T polymorphism and the risk of breast cancer". Anticancer Res. 24 (1): 199–201. PMID 15015597.
- Ahokas K, Lohi J, Illman SA et al. (2004). "Matrix metalloproteinase-21 is expressed epithelially during development and in cancer and is up-regulated by transforming growth factor-beta1 in keratinocytes". Lab. Invest. 83 (12): 1887–99. doi:10.1097/01.LAB.0000106721.86126.39. PMID 14691307.
- Marchenko GN, Marchenko ND, Strongin AY (2003). "The structure and regulation of the human and mouse matrix metalloproteinase-21 gene and protein". Biochem. J. 372 (Pt 2): 503–15. doi:10.1042/BJ20030174. PMC 1223413. PMID 12617721.
- Ahokas K, Lohi J, Lohi H et al. (2003). "Matrix metalloproteinase-21, the human orthologue for XMMP, is expressed during fetal development and in cancer". Gene 301 (1–2): 31–41. doi:10.1016/S0378-1119(02)01088-0. PMID 12490321.
External links
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