MMP14

Matrix metallopeptidase 14 (membrane-inserted)

PDB rendering based on 1bqq.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1BQQ, 1BUV, 3C7X, 3MA2

Identifiers

Symbols

MMP14 ; MMP-14; MMP-X1; MT-MMP; MT-MMP 1; MT1-MMP; MT1MMP; MTMMP1; WNCHRS

External IDs

OMIM: 600754 MGI: 101900 HomoloGene: 21040 IUPHAR: 1638 ChEMBL: 3869 GeneCards: MMP14 Gene

EC number

3.4.24.80

Gene ontology
Molecular function	• sequence-specific DNA binding transcription factor activity • metalloendopeptidase activity • integrin binding • calcium ion binding • protein binding • zinc ion binding • peptidase activator activity
Cellular component	• cytoplasm • Golgi lumen • plasma membrane • integral component of plasma membrane • extracellular matrix • melanosome
Biological process	• ossification • angiogenesis • ovarian follicle development • response to hypoxia • endothelial cell proliferation • regulation of transcription, DNA-templated • proteolysis • response to oxidative stress • male gonad development • response to mechanical stimulus • positive regulation of peptidase activity • extracellular matrix disassembly • extracellular matrix organization • positive regulation of cell growth • lung development • positive regulation of cell migration • collagen catabolic process • zymogen activation • astrocyte cell migration • response to estrogen • branching morphogenesis of an epithelial tube • tissue remodeling • negative regulation of focal adhesion assembly
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 14:
23.31 – 23.32 Mb

Chr 14:
54.43 – 54.44 Mb

PubMed search

Matrix metalloproteinase-14 is an enzyme that in humans is encoded by the MMP14 gene.^[1]

Function

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. "This protein activates MMP2 protein, and this activity may be involved in tumor invasion."^[2]

Interactions

MMP14 has been shown to interact with TIMP2.^[3]

References

↑ Sato H, Takino T, Okada Y, Cao J, Shinagawa A, Yamamoto E et al. (Jul 1994). "A matrix metalloproteinase expressed on the surface of invasive tumour cells". Nature 370 (6484): 61–5. doi:10.1038/370061a0. PMID 8015608.
↑ "Entrez Gene: MMP14 matrix metallopeptidase 14 (membrane-inserted)".
↑ Zucker S, Drews M, Conner C, Foda HD, DeClerck YA, Langley KE et al. (Jan 1998). "Tissue inhibitor of metalloproteinase-2 (TIMP-2) binds to the catalytic domain of the cell surface receptor, membrane type 1-matrix metalloproteinase 1 (MT1-MMP)". J. Biol. Chem. 273 (2): 1216–22. doi:10.1074/jbc.273.2.1216. PMID 9422789.