MLLT3

Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2LM0

Identifiers

MLLT3 ; AF9; YEATS3

External IDs

OMIM: 159558 MGI: 1917372 HomoloGene: 37933 GeneCards: MLLT3 Gene

Gene ontology
Molecular function	• protein binding
Cellular component	• nucleus • extracellular vesicular exosome
Biological process	• transcription, DNA-templated • regulation of transcription, DNA-templated • segment specification • anterior/posterior pattern specification • negative regulation of canonical Wnt signaling pathway • positive regulation of Wnt signaling pathway, planar cell polarity pathway
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000171843

ENSMUSG00000028496

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 9:
20.34 – 20.62 Mb

Chr 4:
87.77 – 88.03 Mb

PubMed search

Protein AF-9 is a protein that in humans is encoded by the MLLT3 gene.^[1]^[2]^[3]

Interactions

MLLT3 has been shown to interact with BCOR.^[4]

References

↑ Nakamura T, Alder H, Gu Y, Prasad R, Canaani O, Kamada N, Gale RP, Lange B, Crist WM, Nowell PC et al. (Jul 1993). "Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs". Proc Natl Acad Sci U S A 90 (10): 4631–5. doi:10.1073/pnas.90.10.4631. PMC 46566. PMID 8506309.
↑ Iida S, Seto M, Yamamoto K, Komatsu H, Tojo A, Asano S, Kamada N, Ariyoshi Y, Takahashi T, Ueda R (Nov 1993). "MLLT3 gene on 9p22 involved in t(9;11) leukemia encodes a serine/proline rich protein homologous to MLLT1 on 19p13". Oncogene 8 (11): 3085–92. PMID 8414510.
↑ "Entrez Gene: MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3".
↑ Srinivasan, R Sathish; de Erkenez Andrea C; Hemenway Charles S (May 2003). "The mixed lineage leukemia fusion partner AF9 binds specific isoforms of the BCL-6 corepressor". Oncogene (England) 22 (22): 3395–406. doi:10.1038/sj.onc.1206361. ISSN 0950-9232. PMID 12776190.

Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Huynh KD, Fischle W, Verdin E, Bardwell VJ (2000). "BCoR, a novel corepressor involved in BCL-6 repression.". Genes Dev. 14 (14): 1810–23. doi:10.1101/gad.14.14.1810. PMC 316791. PMID 10898795.
García-Cuéllar MP, Zilles O, Schreiner SA et al. (2001). "The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3.". Oncogene 20 (4): 411–9. doi:10.1038/sj.onc.1204108. PMID 11313972.
Hemenway CS, de Erkenez AC, Gould GC (2001). "The polycomb protein MPc3 interacts with AF9, an MLL fusion partner in t(9;11)(p22;q23) acute leukemias.". Oncogene 20 (29): 3798–805. doi:10.1038/sj.onc.1204478. PMID 11439343.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Srinivasan RS, de Erkenez AC, Hemenway CS (2003). "The mixed lineage leukemia fusion partner AF9 binds specific isoforms of the BCL-6 corepressor.". Oncogene 22 (22): 3395–406. doi:10.1038/sj.onc.1206361. PMID 12776190.
Erfurth F, Hemenway CS, de Erkenez AC, Domer PH (2004). "MLL fusion partners AF4 and AF9 interact at subnuclear foci.". Leukemia 18 (1): 92–102. doi:10.1038/sj.leu.2403200. PMID 14603337.
Montemurro L, Tonelli R, Fazzina R et al. (2004). "Identification of two MLL-MLLT3 (alias MLL-AF9) chimeric transcripts in the MOLM-13 cell line.". Cancer Genet. Cytogenet. 154 (1): 96–7. doi:10.1016/j.cancergencyto.2004.01.029. PMID 15381384.
Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Martino V, Tonelli R, Montemurro L et al. (2006). "Down-regulation of MLL-AF9, MLL and MYC expression is not obligatory for monocyte-macrophage maturation in AML-M5 cell lines carrying t(9;11)(p22;q23).". Oncol. Rep. 15 (1): 207–11. doi:10.3892/or.15.1.207. PMID 16328057.