MLLT10
| Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | MLLT10 ; AF10 | ||||||||||||
| External IDs | OMIM: 602409 MGI: 1329038 HomoloGene: 20973 GeneCards: MLLT10 Gene | ||||||||||||
| |||||||||||||
| RNA expression pattern | |||||||||||||
 | |||||||||||||
| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 8028 | 17354 | |||||||||||
| Ensembl | ENSG00000078403 | ENSMUSG00000026743 | |||||||||||
| UniProt | P55197 | O54826 | |||||||||||
| RefSeq (mRNA) | NM_001009569 | NM_001252560 | |||||||||||
| RefSeq (protein) | NP_001182555 | NP_001239489 | |||||||||||
| Location (UCSC) | Chr 10: 21.82 – 22.03 Mb | Chr 2: 18.06 – 18.21 Mb | |||||||||||
| PubMed search | |||||||||||||
Protein AF-10 is a protein that in humans is encoded by the MLLT10 gene.[1][2]
Interactions
MLLT10 has been shown to interact with SS18.[3]
References
- ↑ Chaplin T, Ayton P, Bernard OA, Saha V, Della Valle V, Hillion J et al. (Apr 1995). "A novel class of zinc finger/leucine zipper genes identified from the molecular cloning of the t(10;11) translocation in acute leukemia". Blood 85 (6): 1435–41. PMID 7888665.
- ↑ "Entrez Gene: MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10".
- ↑ de Bruijn DR, dos Santos NR, Thijssen J, Balemans M, Debernardi S, Linder B et al. (May 2001). "The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10". Oncogene 20 (25): 3281–9. doi:10.1038/sj.onc.1204419. PMID 11423977.
Further reading
- Silliman CC, McGavran L, Wei Q, Miller LA, Li S, Hunger SP (1998). "Alternative splicing in wild-type AF10 and CALM cDNAs and in AF10-CALM and CALM-AF10 fusion cDNAs produced by the t(10;11)(p13-14;q14-q21) suggests a potential role for truncated AF10 polypeptides". Leukemia 12 (9): 1404–10. doi:10.1038/sj.leu.2401109. PMID 9737689.
- Linder B, Newman R, Jones LK, Debernardi S, Young BD, Freemont P et al. (2000). "Biochemical analyses of the AF10 protein: the extended LAP/PHD-finger mediates oligomerisation". J. Mol. Biol. 299 (2): 369–78. doi:10.1006/jmbi.2000.3766. PMID 10860745.
- Lillington DM, Jaju RJ, Shankar AG, Neat M, Kearney L, Young BD et al. (2000). "Cytogenetic and molecular evidence of marrow involvement in extramedullary acute myeloid leukaemia". Br. J. Haematol. 110 (3): 547–51. doi:10.1046/j.1365-2141.2000.02212.x. PMID 10997963.
- de Bruijn DR, dos Santos NR, Thijssen J, Balemans M, Debernardi S, Linder B et al. (2001). "The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10". Oncogene 20 (25): 3281–9. doi:10.1038/sj.onc.1204419. PMID 11423977.
- Debernardi S, Bassini A, Jones LK, Chaplin T, Linder B, de Bruijn DR et al. (2002). "The MLL fusion partner AF10 binds GAS41, a protein that interacts with the human SWI/SNF complex". Blood 99 (1): 275–81. doi:10.1182/blood.V99.1.275. PMID 11756182.
- Cai Y, Gao Y, Sheng Q, Miao S, Cui X, Wang L et al. (2002). "Characterization and potential function of a novel testis-specific nucleoporin BS-63". Mol. Reprod. Dev. 61 (1): 126–34. doi:10.1002/mrd.1139. PMID 11774384.
- Roll P, Zattara-Cannoni H, Bustos-Bernard MC, Curtillet C, Michel G, Vagner-Capodano AM (2002). "Molecular and fluorescence in situ hybridization analysis of a 10;11 rearrangement in a case of infant acute monocytic leukemia". Cancer Genet. Cytogenet. 135 (2): 187–91. doi:10.1016/S0165-4608(01)00644-6. PMID 12127405.
- Nakamura T, Mori T, Tada S, Krajewski W, Rozovskaia T, Wassell R et al. (2002). "ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation". Mol. Cell 10 (5): 1119–28. doi:10.1016/S1097-2765(02)00740-2. PMID 12453419.
- Perrin L, Bloyer S, Ferraz C, Agrawal N, Sinha P, Dura JM (2003). "The leucine zipper motif of the Drosophila AF10 homologue can inhibit PRE-mediated repression: implications for leukemogenic activity of human MLL-AF10 fusions". Mol. Cell. Biol. 23 (1): 119–30. doi:10.1128/MCB.23.1.119-130.2003. PMC 140655. PMID 12482966.
- Okada Y, Feng Q, Lin Y, Jiang Q, Li Y, Coffield VM et al. (2005). "hDOT1L links histone methylation to leukemogenesis". Cell 121 (2): 167–78. doi:10.1016/j.cell.2005.02.020. PMID 15851025.