MINE (chemotherapy)
MINE in the context of chemotherapy is an acronym for one of the chemotherapy regimens used for treatment of relapsed or refractory aggressive non-Hodgkin's lymphoma and Hodgkin lymphoma as well.
Today this regimen is often combined with monoclonal antibody rituximab. In this case the regimen is called R-MINE or MINE-R.
The [R]-MINE regimen consists of:
- (R)ituximab - anti-CD20 monoclonal antibody that can kill both normal CD20-expressing B cells and malignant ones;
- (M)esna to prevent the development of hemorrhagic cystitis which may otherwise result from ifosfamide administration;
- (I)fosfamide - an alkylating antineoplastic agent from oxazafosforine group;
- (N)ovantrone - a synthetic antracycline analogue (antraquinone) that is able to intercalate DNA and thus prevent cell division (mitosis);
- (E)toposide - a topoisomerase inhibitor.[1][2]
Dosing regimen
| Drug | Dose | Mode | Days |
|---|---|---|---|
| (R)ituximab | 375 mg/m2 | IV infusion | Day 1 |
| (M)esna | 1330 mg/m2 | IV infusion over 1h together with ifosfamide, plus 500 mg PO 4h after ifosfamide | Days 1-3 |
| (I)fosfamide | 1330 mg/m2 | IV infusion over 1h | Days 1-3 |
| (N)ovantrone | 8 mg/m2 | IV infusion | Day 1 |
| (E)toposide | 65 mg/m2 | IV infusion over 1h | Days 1-3 |