MICAL2

Microtubule associated monooxygenase, calponin and LIM domain containing 2

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2E9K

Identifiers

MICAL2 ; MICAL-2; MICAL2PV1; MICAL2PV2

External IDs

OMIM: 608881 MGI: 2444947 HomoloGene: 8760 GeneCards: MICAL2 Gene

Gene ontology
Molecular function	• actin binding • zinc ion binding • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen • NADPH:sulfur oxidoreductase activity • FAD binding
Cellular component	• nucleus
Biological process	• heart looping • cytoskeleton organization • heart development • positive regulation of transcription via serum response element binding • sulfur oxidation • actin filament depolymerization • oxidation-reduction process
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000133816

ENSMUSG00000038244

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 11:
12.12 – 12.29 Mb

Chr 7:
112.23 – 112.36 Mb

PubMed search

Protein MICAL-2 is a protein that in humans is encoded by the MICAL2 gene.^[1]^[2]

References

↑ Terman JR, Mao T, Pasterkamp RJ, Yu HH, Kolodkin AL (Jul 2002). "MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion". Cell 109 (7): 887–900. doi:10.1016/S0092-8674(02)00794-8. PMID 12110185.
↑ "Entrez Gene: MICAL2 microtubule associated monoxygenase, calponin and LIM domain containing 2".

Further reading

Andersson B, Wentland MA, Ricafrente JY et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Nagase T, Ishikawa K, Suyama M et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Fischer J, Weide T, Barnekow A (2005). "The MICAL proteins and rab1: a possible link to the cytoskeleton?". Biochem. Biophys. Res. Commun. 328 (2): 415–23. doi:10.1016/j.bbrc.2004.12.182. PMID 15694364.
Ashida S, Furihata M, Katagiri T et al. (2006). "Expression of novel molecules, MICAL2-PV (MICAL2 prostate cancer variants), increases with high Gleason score and prostate cancer progression.". Clin. Cancer Res. 12 (9): 2767–73. doi:10.1158/1078-0432.CCR-05-1995. PMID 16675569.