MEX3D

Mex-3 homolog D (C. elegans)
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
SymbolsMEX3D ; MEX-3D; MEX3; OK/SW-cl.4; RKHD1; RNF193; TINO
External IDsOMIM: 611009 MGI: 2681847 HomoloGene: 16890 GeneCards: MEX3D Gene
Orthologs
SpeciesHumanMouse
Entrez399664237400
EnsemblENSG00000181588ENSMUSG00000048696
UniProtQ86XN8Q3UE17
RefSeq (mRNA)NM_001174118NM_198615
RefSeq (protein)NP_001167589NP_941017
Location (UCSC)Chr 19:
1.55 – 1.57 Mb		Chr 10:
80.38 – 80.39 Mb
PubMed search

Mex-3 homolog D (C. elegans), also known as MEX3D, is a protein that in humans is encoded by the MEX3D gene.[1][2]

Function

MEX3D is an RNA binding protein that interacts with AU-rich elements of Bcl-2. Upon binding, MEX3D has a negative regulatory action on Bcl-2 expression at the posttranscriptional level.[2]

Structure

MEX3 proteins contain two N-terminal heterogeneous nuclear ribonucleoprotein K homology motifs ( KH domain ) and a RING domain at the C-terminus.[2]

References

  1. ↑ "Entrez Gene: mex-3 homolog D (C. elegans)".
  2. ↑ 2.0 2.1 2.2 Donnini M, Lapucci A, Papucci L, Witort E, Jacquier A, Brewer G, Nicolin A, Capaccioli S, Schiavone N (May 2004). "Identification of TINO: a new evolutionarily conserved BCL-2 AU-rich element RNA-binding protein". J. Biol. Chem. 279 (19): 20154–66. doi:10.1074/jbc.M314071200. PMID 14769789.

Further reading