METAP1
| Methionyl aminopeptidase 1 |
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PDB rendering based on 2b3h. |
| Available structures |
| PDB |
Ortholog search: PDBe, RCSB |
| List of PDB id codes |
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2B3H, 2B3K, 2B3L, 2G6P, 2GZ5, 2NQ6, 2NQ7, 4FLI, 4FLJ, 4FLK, 4FLL, 4HXX, 4IKR, 4IKS, 4IKT, 4IKU, 4IU6
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| Identifiers |
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| Symbols | METAP1 ; MAP1A; MetAP1A |
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| External IDs | OMIM: 610151 HomoloGene: 6488 IUPHAR: 1572 ChEMBL: 2474 GeneCards: METAP1 Gene |
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| EC number | 3.4.11.18 |
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| RNA expression pattern |
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| More reference expression data |
| Orthologs |
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| Species | Human | Mouse | |
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| Entrez | 23173 | 75624 | |
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| Ensembl | ENSG00000164024 | ENSMUSG00000005813 | |
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| UniProt | P53582 | Q8BP48 | |
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| RefSeq (mRNA) | NM_015143 | NM_175224 | |
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| RefSeq (protein) | NP_055958 | NP_780433 | |
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| Location (UCSC) | Chr 4:
99.92 – 99.98 Mb | Chr 3:
138.46 – 138.49 Mb | |
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| PubMed search | | | |
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Methionine aminopeptidase 1 is an enzyme that in humans is encoded by the METAP1 gene.[1][2][3]
References
- ↑ Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H et al. (Jul 1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.
- ↑ Dummitt B, Fei Y, Chang YH (Jul 2002). "Functional expression of human methionine aminopeptidase type 1 in Saccharomyces cerevisiae". Protein Pept Lett 9 (4): 295–303. doi:10.2174/0929866023408607. PMID 12144506.
- ↑ "Entrez Gene: METAP1 methionyl aminopeptidase 1".
Further reading
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Serero A, Giglione C, Sardini A et al. (2004). "An unusual peptide deformylase features in the human mitochondrial N-terminal methionine excision pathway.". J. Biol. Chem. 278 (52): 52953–63. doi:10.1074/jbc.M309770200. PMID 14532271.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rush J, Moritz A, Lee KA et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
- Andersen JS, Lam YW, Leung AK et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
- Addlagatta A, Hu X, Liu JO, Matthews BW (2006). "Structural basis for the functional differences between type I and type II human methionine aminopeptidases.". Biochemistry 44 (45): 14741–9. doi:10.1021/bi051691k. PMID 16274222.
- Kimura K, Wakamatsu A, Suzuki Y et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Selvakumar P, Lakshmikuttyamma A, Dimmock JR, Sharma RK (2006). "Methionine aminopeptidase 2 and cancer.". Biochim. Biophys. Acta 1765 (2): 148–54. doi:10.1016/j.bbcan.2005.11.001. PMID 16386852.
- Hu X, Addlagatta A, Lu J et al. (2007). "Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression.". Proc. Natl. Acad. Sci. U.S.A. 103 (48): 18148–53. doi:10.1073/pnas.0608389103. PMC 1838721. PMID 17114291.
- Ewing RM, Chu P, Elisma F et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
PDB gallery |
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| | 2b3h: Crystal structure of Human Methionine Aminopeptidase Type I with a third cobalt in the active site |
| 2b3k: Crystal structure of Human Methionine Aminopeptidase Type I in the holo form |
| 2b3l: Crystal structure of type I human methionine aminopeptidase in the apo form |
| 2g6p: Crystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in complex with Pyridyl pyrimidine derivative |
| 2gz5: Human Type 1 methionine aminopeptidase in complex with ovalicin at 1.1 Ang |
| 2nq6: Crystal structure of human methionine aminopeptidase type 1 in complex with 3-tert-Butoxycarbonylaminopyridine-2-carboxylic acid thiazole-2-ylamide |
| 2nq7: Crystal structure of type 1 human methionine aminopeptidase in complex with 3-(2,2-Dimethylpropionylamino)pyridine-2-carboxylic acid thiazole-2-ylamide |
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