MEST (gene)

Mesoderm specific transcript
Identifiers
SymbolsMEST ; PEG1
External IDsOMIM: 601029 MGI: 96968 HomoloGene: 1800 GeneCards: MEST Gene
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez423217294
EnsemblENSG00000106484ENSMUSG00000051855
UniProtQ5EB52Q07646
RefSeq (mRNA)NM_001253900NM_001252292
RefSeq (protein)NP_001240829NP_001239221
Location (UCSC)Chr 7:
130.13 – 130.15 Mb		Chr 6:
30.72 – 30.75 Mb
PubMed search

Mesoderm-specific transcript homolog protein is a protein that in humans is encoded by the MEST gene.[1][2]

This gene encodes a member of the [alpha]/[beta] hydrolase fold family and has isoform-specific imprinting. The loss of imprinting of this gene has been linked to certain types of cancer and may be due to promotor switching. The encoded protein may play a role in development. Three transcript variants encoding two distinct isoforms have been identified for this gene. A pseudogene for this locus is located on chromosome 6.[2]

References

  1. ↑ Nishita Y, Yoshida I, Sado T, Takagi N (Feb 1997). "Genomic imprinting and chromosomal localization of the human MEST gene". Genomics 36 (3): 539–42. doi:10.1006/geno.1996.0502. PMID 8884280.
  2. ↑ 2.0 2.1 "Entrez Gene: MEST mesoderm specific transcript homolog (mouse)".

Further reading

  • Kobayashi S, Kohda T, Miyoshi N et al. (1997). "Human PEG1/MEST, an imprinted gene on chromosome 7". Hum. Mol. Genet. 6 (5): 781–6. doi:10.1093/hmg/6.5.781. PMID 9158153.
  • Riesewijk AM, Hu L, Schulz U et al. (1997). "Monoallelic expression of human PEG1/MEST is paralleled by parent-specific methylation in fetuses". Genomics 42 (2): 236–44. doi:10.1006/geno.1997.4731. PMID 9192843.
  • Cuisset L, Le Stunff C, Dupont JM et al. (1998). "PEG1 expression in maternal uniparental disomy 7". Ann. Genet. 40 (4): 211–5. PMID 9526615.
  • Riesewijk AM, Blagitko N, Schinzel AA et al. (1998). "Evidence against a major role of PEG1/MEST in Silver-Russell syndrome". Eur. J. Hum. Genet. 6 (2): 114–20. doi:10.1038/sj.ejhg.5200164. PMID 9781054.
  • Pedersen IS, Dervan PA, Broderick D et al. (1999). "Frequent loss of imprinting of PEG1/MEST in invasive breast cancer". Cancer Res. 59 (21): 5449–51. PMID 10554015.
  • Kosaki K, Kosaki R, Craigen WJ, Matsuo N (2000). "Isoform-Specific Imprinting of the Human PEG1/MEST Gene". Am. J. Hum. Genet. 66 (1): 309–12. doi:10.1086/302712. PMC 1288335. PMID 10631159.
  • Mayer W, Hemberger M, Frank HG et al. (2000). "Expression of the imprinted genes MEST/Mest in human and murine placenta suggests a role in angiogenesis". Dev. Dyn. 217 (1): 1–10. doi:10.1002/(SICI)1097-0177(200001)217:1<1::AID-DVDY1>3.0.CO;2-4. PMID 10679925.
  • Hayashida S, Yamasaki K, Asada Y et al. (2000). "Construction of a physical and transcript map flanking the imprinted MEST/PEG1 region at 7q32". Genomics 66 (2): 221–5. doi:10.1006/geno.2000.6206. PMID 10860668.
  • Russo S, Bedeschi MF, Cogliati F et al. (2000). "Maternal chromosome 7 hetero/isodisomy in Silver-Russell syndrome and PEG1 biallelic expression". Clin. Dysmorphol. 9 (3): 157–62. doi:10.1097/00019605-200009030-00001. PMID 10955473.
  • Kerjean A, Dupont JM, Vasseur C et al. (2000). "Establishment of the paternal methylation imprint of the human H19 and MEST/PEG1 genes during spermatogenesis". Hum. Mol. Genet. 9 (14): 2183–7. doi:10.1093/hmg/9.14.2183. PMID 10958657.
  • Kohda M, Hoshiya H, Katoh M et al. (2001). "Frequent loss of imprinting of IGF2 and MEST in lung adenocarcinoma". Mol. Carcinog. 31 (4): 184–91. doi:10.1002/mc.1053. PMID 11536368.
  • Miozzo M, Grati FR, Bulfamante G et al. (2002). "Post-zygotic origin of complete maternal chromosome 7 isodisomy and consequent loss of placental PEG1/MEST expression". Placenta 22 (10): 813–21. doi:10.1053/plac.2001.0728. PMID 11718568.
  • Kobayashi S, Uemura H, Kohda T et al. (2002). "No evidence of PEG1/MEST gene mutations in Silver-Russell syndrome patients". Am. J. Med. Genet. 104 (3): 225–31. doi:10.1002/ajmg.10022. PMID 11754049.
  • Li T, Vu TH, Lee KO et al. (2002). "An imprinted PEG1/MEST antisense expressed predominantly in human testis and in mature spermatozoa". J. Biol. Chem. 277 (16): 13518–27. doi:10.1074/jbc.M200458200. PMID 11821432.
  • Bonora E, Bacchelli E, Levy ER et al. (2002). "Mutation screening and imprinting analysis of four candidate genes for autism in the 7q32 region". Mol. Psychiatry 7 (3): 289–301. doi:10.1038/sj.mp.4001004. PMID 11920156.
  • Pedersen IS, Dervan P, McGoldrick A et al. (2002). "Promoter switch: a novel mechanism causing biallelic PEG1/MEST expression in invasive breast cancer". Hum. Mol. Genet. 11 (12): 1449–53. doi:10.1093/hmg/11.12.1449. PMID 12023987.
  • Nakabayashi K, Bentley L, Hitchins MP et al. (2003). "Identification and characterization of an imprinted antisense RNA (MESTIT1) in the human MEST locus on chromosome 7q32". Hum. Mol. Genet. 11 (15): 1743–56. doi:10.1093/hmg/11.15.1743. PMID 12095916.
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Scherer SW, Cheung J, MacDonald JR et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.